{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T17:53:34Z","timestamp":1770400414350,"version":"3.49.0"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Synchronous ovarian tumors of different histogenesis are rare. High-grade serous carcinoma (HGSC) is an aggressive epithelial malignancy that primarily affects postmenopausal women, whereas mature cystic teratoma is a benign germ cell tumor usually seen in younger patients. Their occurrence in contralateral ovaries poses significant diagnostic challenges. A 57-year-old postmenopausal woman presented with abdominal distension, discomfort, and ascites. Imaging revealed a solid-cystic right ovarian mass with peritoneal involvement and a left adnexal lesion showing fat\u2013fluid levels suggestive of a dermoid cyst. CA-125 was markedly elevated, and ascitic cytology confirmed malignant epithelial cells. She underwent a hysterectomy with bilateral salpingo-oophorectomy and omentectomy. Histopathology showed high-grade serous carcinoma in the right ovary with tubal and cervical stromal invasion, while the left ovary contained a benign mature cystic teratoma. Immunohistochemistry supported M\u00fcllerian origin (WT-1+, PAX8+, p53 mutant pattern, and high Ki-67). The tumor was staged as FIGO IIIC. Postoperative platinum-based chemotherapy resulted in significant clinical improvement, CA-125 reduction, and no recurrence at 9 months. This synchronous presentation underscores the importance of correlating imaging, cytology, extensive sampling, and immunohistochemistry to distinguish independent tumors from bilateral carcinoma. Accurate diagnosis enables appropriate oncologic management while avoiding overtreatment of benign lesions.<\/jats:p>","DOI":"10.3389\/fmed.2026.1729956","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T06:36:10Z","timestamp":1770359770000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: A rare case of serous cystadenocarcinoma of the ovary with a benign teratoma in the other ovary"],"prefix":"10.3389","volume":"13","author":[{"given":"Abhishek","family":"Ghose Biswas","sequence":"first","affiliation":[{"name":"Department of Pathology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research","place":["Wardha, Maharashtra, India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kishore","family":"Hiwale","sequence":"additional","affiliation":[{"name":"Department of Pathology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research","place":["Wardha, Maharashtra, India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"252","DOI":"10.17659\/01.2015.0064","article-title":"Huge bilateral serous papillary cystadenocarcinoma","volume":"5","author":"Katke","year":"2015","journal-title":"J Clin Res"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e3818","DOI":"10.7759\/cureus.3818","article-title":"Benign ovarian tumors in pregnancy: a case report of Metachronous ipsilateral recurrent mucinous cystadenoma in initial pregnancy and mature cystic Teratoma in subsequent pregnancy","volume":"11","author":"Schreck","year":"2019","journal-title":"Cureus"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"201","DOI":"10.4103\/cjhr.cjhr_20_17","article-title":"A rare case of collision tumor: massive mucinous cystadenoma and benign mature cystic teratoma arising in the same ovary","volume":"4","author":"Reddy","year":"2017","journal-title":"CHRISMED J Health Res"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.3390\/curroncol31040144","article-title":"High-grade serous ovarian Cancer during pregnancy: from diagnosis to treatment","volume":"31","author":"Vivod","year":"2024","journal-title":"Curr Oncol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1186\/s13256-024-04544-w","article-title":"Mature cystic teratoma with co-existent mucinous cystadenocarcinoma: describing a diagnostic challenge-a case report","volume":"18","author":"Chahkandi","year":"2024","journal-title":"J Med Case Rep"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e58068","DOI":"10.7759\/cureus.58068","article-title":"Co-existence of ovarian Teratomas with other gynecological tumors","volume":"16","author":"Matalliotakis","year":"2024","journal-title":"Cureus"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.radcr.2023.10.030","article-title":"Mature cystic teratoma overlapping with giant serous cystadenoma of the ovary: a case report","volume":"19","author":"Grisales-Gallo","year":"2023","journal-title":"Radiol Case Rep"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"26","DOI":"10.18632\/oncoscience.616","article-title":"Cystadenofibroma and contralateral collision lesions: A unique ovarian case report","volume":"12","author":"Kumar","year":"2025","journal-title":"Oncoscience"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"ER01","DOI":"10.7860\/JCDR\/2022\/56624.16462","article-title":"Uncommon pathological presentations of mature cystic teratoma: a case series","volume":"16","author":"Pant","year":"2022","journal-title":"J Clin Diagn Res"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"3275","DOI":"10.1016\/j.radcr.2021.07.073","article-title":"Malignant degeneration of mature cystic teratoma of the ovary with small bowel metastasis incidental serous cystadenoma collision tumor of the right ovary","volume":"16","author":"Abduljabbar","year":"2021","journal-title":"Radiol Case Rep"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2773","DOI":"10.1007\/s00330-010-1886-4","article-title":"European Society of Urogenital Radiology. 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