{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:59:48Z","timestamp":1780635588033,"version":"3.54.1"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wu Jieping Medical Foundation Program","award":["320.6750.2022-03-45"],"award-info":[{"award-number":["320.6750.2022-03-45"]}]},{"name":"Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education","award":["2025 Open Project-6"],"award-info":[{"award-number":["2025 Open Project-6"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prostate cancer (PCa) is the second most frequently diagnosed malignancy in men worldwide, whereas benign prostatic hyperplasia (BPH) is among the most prevalent non-malignant prostatic disorders. Differentiating between these two conditions remains challenging because of overlapping clinical manifestations and the limited specificity of currently available biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study enrolled 200 male patients (53 PCa, 147 BPH) who underwent prostate biopsy or surgical resection based on pathological diagnosis. Clinical characteristics, laboratory parameters, and inflammatory indices were compared between the groups. Both univariate and multivariate logistic regression analyses were conducted to identify independent predictors. Nomograms were developed and validated through calibration curves, ROC analysis, and decision curve analysis (DCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PCa patients had significantly higher levels of inflammatory markers than BPH patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). In multivariate analysis, log2-SII (OR\u202f=\u202f2.22, 95% CI: 1.13\u20134.37,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.021) and log2-AISI (OR\u202f=\u202f3.27, 95% CI: 1.83\u20135.85,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001) emerged as independent risk factors for PCa. The AISI-based model achieved superior diagnostic performance with an AUC of 0.878 (95% CI: 0.825\u20130.931) compared with the SII-based model (AUC\u202f=\u202f0.855, 95% CI: 0.794\u20130.915). DCA showed greater clinical net benefit for the AISI model across a wide range of threshold probabilities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Blood inflammatory markers, particularly AISI, in combination with conventional biomarkers, offer enhanced diagnostic accuracy for differentiating BPH from PCa, representing a non-invasive and cost-effective approach for clinical decision-making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1730818","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T06:40:45Z","timestamp":1770187245000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Blood inflammatory markers combined with tumor markers for differentiating benign prostatic hyperplasia from prostate cancer"],"prefix":"10.3389","volume":"13","author":[{"given":"Zeqiang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Peking University Third Hospital","place":["Beijing, China"]},{"name":"Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinji","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology, Peking University Third Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Urology, Peking University Third Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Du","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education","place":["Beijing, China"]},{"name":"Department of Urology, Peking University Cancer Hospital and Institute","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keke","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Peking University Third Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/s41585-018-0060-7","article-title":"Landmarks in prostate cancer","volume":"15","author":"Sathianathen","year":"2018","journal-title":"Nat Rev Urol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.eururo.2020.09.042","article-title":"EAU-EANM-ESTRO-ESUR-SIOG guidelines on prostate cancer-2020 update. Part 1: screening, diagnosis, and local treatment with curative intent","volume":"79","author":"Mottet","year":"2021","journal-title":"Eur Urol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1016\/j.eururo.2013.05.049","article-title":"Systematic review of complications of prostate biopsy","volume":"64","author":"Loeb","year":"2013","journal-title":"Eur Urol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.urology.2016.12.011","article-title":"Prostate biopsy-related infection: a systematic review of risk factors, prevention strategies, and management approaches","volume":"104","author":"Roberts","year":"2017","journal-title":"Urology"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1016\/j.juro.2010.12.032","article-title":"A multicenter study of [\u22122]pro-prostate specific antigen combined with prostate specific antigen and free prostate specific antigen for prostate cancer detection in the 2.0 to 10.0 ng\/mL prostate specific antigen range","volume":"185","author":"Catalona","year":"2011","journal-title":"J Urol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/s41391-017-0024-7","article-title":"Prostate-specific antigen (PSA) density in the diagnostic algorithm of prostate cancer","volume":"21","author":"Nordstr\u00f6m","year":"2018","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/978-3-319-95693-0_3","article-title":"Inflammation and prostate cancer","volume":"1095","author":"Tewari","year":"2018","journal-title":"Adv Exp Med Biol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/j.1365-2559.2011.04033.x","article-title":"Prostate cancer and inflammation: the 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