{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T23:07:10Z","timestamp":1769123230599,"version":"3.49.0"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010950","name":"Science and Technology Department, Henan Province","doi-asserted-by":"publisher","award":["LHG20240970"],"award-info":[{"award-number":["LHG20240970"]}],"id":[{"id":"10.13039\/501100010950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013066","name":"Key Scientific Research Project of Colleges and Universities in Henan Province","doi-asserted-by":"publisher","award":["No. 23A320036"],"award-info":[{"award-number":["No. 23A320036"]}],"id":[{"id":"10.13039\/501100013066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Severe organ function deterioration is associated with poor prognosis in patients with septic shock combined with ARDS. This study aimed to develop a validated predictive model for early organ function deterioration and to evaluate the factors associated with this deterioration, as well as the prognosis, in patients with septic shock combined with ARDS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This is a retrospective study including 67 patients with septic shock combined with ARDS. Patients were categorized into two groups based on the change in their Sequential Organ Failure Assessment (SOFA) score over 24 h: the organ function deterioration group (SOFA\n                      <jats:sub>24h \u2212 0h<\/jats:sub>\n                      score \u2265 1) and the non-deterioration group (SOFA\n                      <jats:sub>24h \u2212 0h<\/jats:sub>\n                      score &amp;lt;1). The sublingual microvasculature of patients was assessed using microcirculatory microimaging to obtain metrics such as proportion of perfusion vessel change rate (\u0394PPV), which were then analyzed to characterize the patients with early organ function deterioration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were a total of 34 patients with early organ function deterioration. \u0394PPV and LCR were independently associated with early organ function deterioration, and \u0394PPV and lactate clearance rate (LCR) were associated with \u0394SOFA. The AUC for \u0394PPV was 0.813 (95% CI: 0.707\u20130.919), and when combined with the LCR, the AUC was 0.871 (95% CI: 0.785\u20130.957).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Deterioration of organ function is common in patients with septic shock combined with ARDS and early detection is crucial. Microcirculation is an important factor in safeguarding organ function. We developed a predictive model to predict the risk of early organ function deterioration, and the combination of \u0394PPV and LCR may merit further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1733855","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T06:52:14Z","timestamp":1769064734000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The value of proportion of perfused vessels change rate in the evaluation of early organ function deterioration in septic shock and ARDS"],"prefix":"10.3389","volume":"13","author":[{"given":"Shuya","family":"Huang","sequence":"first","affiliation":[{"name":"Respiratory Intensive Care Unit (RICU), Zhengzhou Central Hospital Affiliated to Zhengzhou University","place":["Zhengzhou, 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