{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:33:35Z","timestamp":1791228815877,"version":"4.1.0"},"reference-count":122,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Ulcerative colitis (UC) is a chronic non-specific inflammatory disease, the pathogenesis is not clear, there is no clinical cure. The number of cases of UC has increased worldwide in recent years due to industrialization and social pressures. At present, the therapeutic effectiveness of UC remains controversial. Although researchers have conducted certain studies on the pathogenesis of UC, its pathogenesis and anti-UC pathogenesis have not been fully revealed. Previous studies have found a close relationship between human gut microbes and UC, and may be the most important measure of UC for clinical judgment. Many studies have linked UC to disruption of the gut microbiome, which is one of the most important features of UC. This paper reviews the clinical characteristics, pathogenesis and current treatment strategies of UC, and reviews the interaction between intestinal flora and UC as well as the therapeutic effects of intestinal flora, providing reference for the prevention and treatment of UC.<\/jats:p>","DOI":"10.3389\/fmed.2026.1735850","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:47:44Z","timestamp":1769518064000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["The current consensus on ulcerative colitis, and the evidence and perspectives on the influence of gut microbiota on it"],"prefix":"10.3389","volume":"13","author":[{"given":"Yufeng","family":"Chen","sequence":"first","affiliation":[{"name":"The First People\u2019s Hospital of Jiashan County","place":["Jiaxing, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University","place":["Wenzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"357","DOI":"10.4103\/ijmr.IJMR_936_18","article-title":"Inflammatory bowel disease","volume":"26","author":"Abraham","year":"2013","journal-title":"Natl Med J India"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1016\/j.cgh.2007.07.012","article-title":"The prevalence and geographic distribution of Crohn's disease and ulcerative colitis in the United States","volume":"5","author":"Kappelman","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1136\/gut.2003.025411","article-title":"Is inflammatory bowel disease an independent and disease specific risk factor for thromboembolism?","volume":"53","author":"Miehsler","year":"2004","journal-title":"Gut"},{"key":"ref4","volume-title":"Extraintestinal manifestations of inflammatory bowel disease","author":"Uyanikoglu","year":"2014"},{"key":"ref5","first-page":"33","article-title":"Clinical manifestation and classification of ulcerative colitis","volume":"8","author":"Jiaming","year":"2008","journal-title":"Mod Dig Interv"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1183\/09031936.00.15104100","article-title":"Clinical and radiological characteristics of lung disease in inflammatory bowel disease","volume":"15","author":"Mahadeva","year":"2000","journal-title":"Eur Respir J"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1373\/clinchem.2005.058560","article-title":"Serologic markers in inflammatory bowel disease","volume":"52","author":"Bossuyt","year":"2006","journal-title":"Clin Chem"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1136\/bmj.2.4947.1041","article-title":"Cortisone in ulcerative colitis; final report on a therapeutic trial","volume":"2","author":"Truelove","year":"1955","journal-title":"BMJ"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"S64","DOI":"10.1007\/bf01312466","article-title":"5-aminosalicylic acid enemas in treatment of distal ulcerative colitis and proctitis in Canada","volume":"32","author":"Sutherland","year":"1987","journal-title":"Dig Dis Sci"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1093\/ecco-jcc\/jjx009","article-title":"Third European evidence-based consensus on diagnosis and management of ulcerative colitis. 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