{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T10:20:02Z","timestamp":1771928402377,"version":"3.50.1"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>This case report evaluates a novel multi-sensory integration training (MSIT) protocol, combining binocular disparate vision perception training with physiotherapeutic scoliosis-specific exercises in two pediatric patients (aged 4 and 5\u202fyears) with comorbid non-syndromic strabismus and idiopathic scoliosis. Both patients presented with intermittent exotropia, amblyopia, and thoracic scoliosis (Cobb angles of 10\u00b0 and 13\u00b0, respectively). Following the individualized MSIT intervention, marked improvements were observed in both visual and spinal parameters: visual acuity of the amblyopic eye improved, exotropia magnitude decreased, stereopsis recovered, and Cobb angles substantially reduced to 3\u00b0 and 0\u00b0, respectively, after 3\u202fmonths. A transient \u201ctreatment plateau\u201d in perceptual eye position metrics was observed in one case before subsequent normalization. These findings suggest that MSIT, by simultaneously addressing aberrant visual and proprioceptive inputs, effectively improves both visual function and spinal alignment in this comorbid population, potentially through promoting central nervous system recalibration of multi-sensory integration for postural control. This integrated approach highlights the importance of interdisciplinary management for children presenting with both strabismus and spinal deformities.<\/jats:p>","DOI":"10.3389\/fmed.2026.1735918","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T05:16:16Z","timestamp":1770009376000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Multi-sensory integration treatment for preschool children with intermittent exotropia and idiopathic scoliosis comorbidity"],"prefix":"10.3389","volume":"13","author":[{"given":"Yu","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University","place":["Guangzhou, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Second People\u2019s Hospital of Foshan, Guangdong Pharmaceutical University","place":["Foshan, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanling","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University","place":["Guangzhou, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yashu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University","place":["Guangzhou, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xidan","family":"Deng","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Healthcare Devices","place":["Guangzhou, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University","place":["Guangzhou, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University","place":["Guangzhou, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanlei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University","place":["Guangzhou, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.1186\/s12889-025-23485-7","article-title":"Prevalence of visual impairment and refractive error-related risk factors in preschool children in Beijing, China","volume":"25","author":"Sun","year":"2025","journal-title":"BMC Public Health"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"20552076231176638","DOI":"10.1177\/20552076231176638","article-title":"Design and assessment of amblyopia, strabismus, and myopia treatment and vision training using virtual 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