{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:16:57Z","timestamp":1787026617434,"version":"build-2736575974"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Technology Innovation R&D Project of Chengdu Science and Technology Bureau","award":["2024-YF05-00521-SN"],"award-info":[{"award-number":["2024-YF05-00521-SN"]}]},{"name":"The Medical Foundation of Sichuan Association","award":["S2024063"],"award-info":[{"award-number":["S2024063"]}]},{"name":"The Natural Science Foundation of Sichuan Province","award":["2024NSFSC1861"],"award-info":[{"award-number":["2024NSFSC1861"]}]},{"name":"The \u201cXinglin Scholar\u201d Discipline Talent Research Enhancement Program of Chengdu University of Traditional Chinese Medicine","award":["QJRC2024027"],"award-info":[{"award-number":["QJRC2024027"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acupuncture is increasingly utilized to address anxiety and depression in polycystic ovary syndrome (PCOS), yet evidence for non-pharmacological interventions remains limited. This study aimed to rigorously evaluate the efficacy and safety of acupuncture in alleviating anxiety and depression among women with PCOS, while exploring its potential mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eight Chinese\/English databases (CNKI, Web of Science, PubMed, Embase, etc.) were searched from inception to March 1, 2025. Two investigators independently screened studies, extracted data, and assessed quality via the Cochrane risk-of-bias tool. The meta-analyses were performed with RevMan 5.4. Additionally, data mining methods were used, including frequency statistics to analyze the frequency of acupuncture points and the meridians involved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twelve RCTs (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f2,127 patients; acupuncture\u202f=\u202f1,059, control\u202f=\u202f1,068) were included. Compared with the control, acupuncture significantly reduced anxiety scores [MD\u202f=\u202f\u22126.42, 95% CI (\u22128.91, \u22123.56);\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.00001] and depression scores [MD\u202f=\u202f\u22125.89, 95% CI (\u22129.01, \u22122.78);\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.0002] versus controls. Acupuncture also improved testosterone [MD\u202f=\u202f\u22120.05, 95% CI (\u22120.11, 0.00);\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.05], BMI [MD\u202f=\u202f\u22120.70, 95% CI (\u22121.19, \u22120.21);\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.005], and the waist-hip ratio [MD\u202f=\u202f\u22120.06, 95% CI (\u22120.11, \u22120.01);\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.03], with no significant adverse effects [OR\u202f=\u202f0.08, 95% CI (0.01, 0.81);\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.03]. The effects on insulin resistance were not significant [MD\u202f=\u202f\u22120.41, 95% CI (\u22121.18, 0.37);\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.31]. Data mining revealed that Foot Taiyin Spleen Meridian (SP), Conception Vessel (CV), and Foot Yangming Stomach Meridian (ST) were the most frequently used, and the most commonly used combination of points included SP6, LR3, and ST36.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Acupuncture, particularly manual and short-term protocols, is a safe and effective adjunct for reducing anxiety and depression in PCOS. These benefits may be mediated via modulation of androgen levels, adiposity, and neuroendocrine pathways. Nevertheless, conclusions are limited by sample size, methodological heterogeneity, and inadequate adverse event reporting. Higher-quality RCTs are needed to confirm the safety and efficacy of these methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration<\/jats:title>\n                    <jats:p>\n                      <jats:uri>https:\/\/www.crd.york.ac.uk\/PROSPERO\/view\/CRD420251000646<\/jats:uri>\n                      , Identifier CRD420251000646.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1738629","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T06:41:10Z","timestamp":1768977670000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Acupuncture improves anxiety and depression in patients with polycystic ovary syndrome: a systematic evaluation and meta-analysis"],"prefix":"10.3389","volume":"13","author":[{"given":"Rongzhen","family":"Ye","sequence":"first","affiliation":[{"name":"School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]},{"name":"Chengdu Pidu District Hospital of Traditional Chinese Medicine","place":["Chengdu, China"]},{"name":"The Third Affiliated Hospital of Chengdu University of Traditional Chinese Medicine (West District)","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujia","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]},{"name":"Chengdu Pidu District Hospital of Traditional Chinese Medicine","place":["Chengdu, China"]},{"name":"The Third Affiliated Hospital of Chengdu University of Traditional Chinese Medicine (West District)","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyun","family":"Tian","sequence":"additional","affiliation":[{"name":"Chengdu Pidu District Hospital of Traditional Chinese Medicine","place":["Chengdu, China"]},{"name":"The Third Affiliated Hospital of Chengdu University of Traditional Chinese Medicine (West District)","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songheng","family":"He","sequence":"additional","affiliation":[{"name":"School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siran","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]},{"name":"Chengdu Pidu District Hospital of Traditional Chinese Medicine","place":["Chengdu, China"]},{"name":"The Third Affiliated Hospital of Chengdu University of Traditional Chinese Medicine (West District)","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yefang","family":"Liu","sequence":"additional","affiliation":[{"name":"Chengdu Pidu District Hospital of Traditional Chinese Medicine","place":["Chengdu, China"]},{"name":"The Third Affiliated Hospital of Chengdu University of Traditional Chinese Medicine (West District)","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13739","article-title":"ESHRE guideline update 2022: new perspectives in the management of couples with recurrent pregnancy loss","volume":"90","author":"Cavalcante","year":"2023","journal-title":"Am J Reprod 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