{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T14:02:59Z","timestamp":1781100179552,"version":"3.54.1"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Hair transplantation is a therapeutic option for androgenic alopecia (AGA) with visible results after 1\u202fyear. Post-transplant care may aid graft survival and growth, though few studies have assessed its efficacy. We evaluated the long-term tolerance and clinical efficacy of a hair serum containing two plant-derived active extracts (\n                      <jats:italic>Silybum marianum<\/jats:italic>\n                      ,\n                      <jats:italic>Lespedeza capitata<\/jats:italic>\n                      ) and manganese PCA, in men undergoing AGA post-hair transplant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this 1-year exploratory randomized controlled trial, hair transplant patients received either study serum with neutral shampoo or shampoo alone. Tolerance and efficacy were evaluated by both investigators and patients at 0.5\u202fmonth (M0.5) then M1, M3, M6, M9 and M12, depending on parameters, compared to baseline (before hair transplant).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty men [median age: 40.0 (26.0\u201364.0) years], 15 per group, were included. Daily use of the serum on the recipient area post hair-transplant in men with AGA improved scalp tightness at M1 and discomfort perceived as painful at M0.5 (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202fNS) and M1 (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05 vs. controls), as well as hair condition at M1 evaluated by patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). The global aspect of the scalp from M1 to M12 and hair growth from M6 to M12 evaluated by investigators showed more pronounced and rapid improvement vs. controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). Serum tolerance and acceptability by patients were excellent.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This first randomized controlled pilot trial suggested that this serum enhances global scalp aspect and hair state and appears to promote hair growth after transplantation, thus acting as a safe, dermocosmetic adjuvant for optimal long-term post-procedure hair care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1740785","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T13:25:56Z","timestamp":1781097956000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A one-year exploratory randomized, controlled, multicentric pilot study evaluating the efficacy and tolerance of an anti-hair loss serum containing Silybum marianum extract, manganese PCA, and Lespedeza capitata extract following hair transplantation in men with androgenic alopecia"],"prefix":"10.3389","volume":"13","author":[{"given":"Daniel","family":"Ortega Quijano","sequence":"first","affiliation":[{"name":"Disorders Unit of the Ram\u00f3n y Cajal University Hospital, Hair Disorders and Hair Transplant Unit of Pedro Ja\u00e9n Group Clinic, University of Alcal\u00e1","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"G\u00f3mez Zubiaur","sequence":"additional","affiliation":[{"name":"Trichology Unit, Ricart Medical Institute","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Babin","sequence":"additional","affiliation":[{"name":"Pierre Fabre Dermo-Cosm\u00e9tique","place":["Toulouse, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Lauze","sequence":"additional","affiliation":[{"name":"Pierre Fabre Dermo-Cosm\u00e9tique","place":["Toulouse, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Froliger","sequence":"additional","affiliation":[{"name":"Pierre Fabre Dermo-Cosm\u00e9tique","place":["Toulouse, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Va\u00f1o-Galvan","sequence":"additional","affiliation":[{"name":"Disorders Unit of the Ram\u00f3n y Cajal University Hospital, Hair Disorders and Hair Transplant Unit of Pedro Ja\u00e9n Group Clinic, University of Alcal\u00e1","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Mengeaud","sequence":"additional","affiliation":[{"name":"Medical Department, Laboratoires Dermatologiques DUCRAY","place":["Lavaur, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1136\/bmj.331.7522.951","article-title":"The psychological impact of alopecia","volume":"331","author":"Hunt","year":"2005","journal-title":"BMJ"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.jaad.2021.03.124","article-title":"Hair transplantation: basic overview","volume":"85","author":"Jimenez","year":"2021","journal-title":"J Am Acad Dermatol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/jdv.14624","article-title":"Evidence-based (S3) guideline for the treatment of androgenetic alopecia in women and in men \u2013 short version","volume":"32","author":"Kanti","year":"2018","journal-title":"J Eur Acad Dermatol 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Dermatol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/jocd.16656","article-title":"A well-tolerated hair serum containing new natural active ingredients reduced hair loss and improved quality of life in women with chronic Telogen effluvium: a 16-week controlled study","volume":"23","author":"Turlier","year":"2024","journal-title":"J Cosmet Dermatol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"5239","DOI":"10.1136\/bmj.i5239","article-title":"CONSORT 2010 statement: extension to randomised pilot and feasibility trials","volume":"355","author":"Eldridge","year":"2016","journal-title":"BMJ"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1111\/j..2002.384.doc.x","article-title":"Design and analysis of pilot studies: recommendations for good practice","volume":"10","author":"Lancaster","year":"2004","journal-title":"J Eval Clin Pract"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2288-10-1","article-title":"A tutorial on pilot studies: the what, why and how","volume":"10","author":"Thabane","year":"2010","journal-title":"BMC Med Res Methodol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1002\/pst.185","article-title":"Sample size of 12 per group rule of thumb for a pilot study","volume":"4","author":"Julious","year":"2005","journal-title":"Pharm Stat J Appl Stat Pharm Ind"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/jdv.17601","article-title":"Current controversies in trichology: a European expert consensus statement","volume":"35","author":"Meyer-Gonzalez","year":"2021","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.det.2012.08.012","article-title":"Hair transplantation update","volume":"31","author":"Kristine Bunagan","year":"2013","journal-title":"Dermatol Clin"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1740785\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T13:25:57Z","timestamp":1781097957000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1740785\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,10]]},"references-count":17,"alternative-id":["10.3389\/fmed.2026.1740785"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1740785","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,10]]},"article-number":"1740785"}}