{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:42:44Z","timestamp":1786992164861,"version":"build-2736575974"},"reference-count":154,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    <jats:italic>Schisandra chinensis<\/jats:italic>\n                    Fructus (SCF) is a traditional Chinese herbal medicine with both medicinal and culinary uses. Its main active ingredients, including lignans, triterpenoids, volatile oils, and organic acids, have been utilized to treat liver diseases. SCF extract exhibits pharmacological activities such as protecting hepatocytes, reducing hepatic fat accumulation, alleviating insulin resistance, and mitigating oxidative stress, thus holding promising application prospects in alleviating metabolic dysfunction-associated steatotic liver disease (MASLD). The aim of our review is to summarize and organize recent literature regarding the active metabolites and pharmacology of SCF, so as to clarify the pharmacological mechanism of this herbal medicine and provide a reference for the research, development, and utilization of SCF, its compound preparations, and related health foods. Literature selection was performed using relevant databases in traditional Chinese medicine and biomedical sciences, based on the ethnopharmacological uses (medicinal and culinary) of SCF. Studies investigating the roles and mechanisms of SCF\u2019s active metabolites in alleviating MASLD were primarily chosen. SCF contains multiple active metabolites, among which lignans, triterpenoids, volatile oils, and organic acids play crucial roles in alleviating MASLD. These metabolites exert pharmacological effects by protecting hepatocytes from damage, regulating hepatic lipid metabolism, improving insulin sensitivity, and resisting oxidative stress, collectively contributing to the mitigation of MASLD. However, systematic exploration of the integrated mechanisms involving these metabolites remains necessary. The active metabolites of SCF possess diverse pharmacological activities in alleviating MASLD. Clarifying their underlying mechanisms is beneficial for promoting further research, development, and application of SCF in medicine and health foods, providing a solid basis for related drug development and functional food utilization.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2026.1743905","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T05:57:43Z","timestamp":1778651863000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Schisandra chinensis Fructus and its active metabolites for the treatment of metabolic dysfunction-associated steatotic liver disease"],"prefix":"10.3389","volume":"13","author":[{"given":"Li Jun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Medicine, Shandong Medical and Pharmaceutical University Yantai","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Shandong Medical and Pharmaceutical University Yantai","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanxiang Hospital","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu Cheng","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Nursing, The Hong Kong Polytechnic University","place":["Kowloon, Hong Kong SAR, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei You","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Shandong Medical and Pharmaceutical University Yantai","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Chun","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Shandong Medical and Pharmaceutical University Yantai","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian Guang","family":"Sun","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College of Shandong University of Traditional Chinese Medicine","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian Chao","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Shanxi Provincial Hospital of Integrated Traditional Chinese and Western Medicine","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Zibo Hospital of Integrated Traditional Chinese and Western Medicine","place":["Zibo, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"114759","DOI":"10.1016\/j.jep.2021.114759","article-title":"A comprehensive review of ethnopharmacology, phytochemistry, pharmacology, and pharmacokinetics of Schisandra chinensis (Turcz.) 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