{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T02:10:49Z","timestamp":1773195049674,"version":"3.50.1"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Varicella-zoster virus (VZV) infection is associated with serious complications, including cranial vasculopathy and herpes zoster ophthalmicus (HZO). Hutchinson\u2019s sign, characterized by VZV lesions on the tip, dorsum, and root of the nose, serves as a strong predictor of ipsilateral ocular complications in HZO. Here we describe a 61-year-old male who developed multiple cranial neuropathies and acute cerebral infarction secondary to VZV infection. His clinical manifestations began with Hutchinson\u2019s sign, progressed to HZO, and subsequently led to acute cerebral infarction and bilateral ophthalmoplegia. The presence of Hutchinson\u2019s sign strongly correlates with the development of HZO-related ocular complications. This striking bilateral cranial nerve involvement and cerebral infarctions suggest a potential mechanism of widespread viral dissemination within the central nervous system.<\/jats:p>","DOI":"10.3389\/fmed.2026.1745425","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T05:30:43Z","timestamp":1773120643000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hutchinson\u2019s sign complicated by bilateral multiple cranial neuropathies and cerebral infarctions: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Zhongzheng","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Neurology, The Second Qilu Hospital of Shandong University","place":["Jinan, China"]},{"name":"Cheeloo College of Medicine of Shandong University","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Qilu Hospital of Shandong University","place":["Jinan, China"]},{"name":"Cheeloo College of Medicine of Shandong University","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianwen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Qilu Hospital of Shandong University","place":["Jinan, China"]},{"name":"Cheeloo College of Medicine of Shandong University","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Qilu Hospital of Shandong University","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Qilu Hospital of Shandong University","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunliang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Qilu Hospital of Shandong University","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Qilu Hospital of Shandong University","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaohong","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Qilu Hospital of Shandong University","place":["Jinan, 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