{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T20:25:01Z","timestamp":1768940701762,"version":"3.49.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    Maternal sepsis is a life-threatening infectious complication, with septic shock linked to high mortality. Coagulopathy is a key feature, but the association between activated partial thromboplastin time (APTT) and maternal septic shock remains unclear. This retrospective study included 1,631 pregnant women with infection admitted from January 2017 to March 2023. Based on admission APTT levels, patients were divided into three groups: &amp;lt;28\u202fs (\n                    <jats:italic>n<\/jats:italic>\n                    \u202f=\u202f697), 28\u201342\u202fs (\n                    <jats:italic>n<\/jats:italic>\n                    \u202f=\u202f915), and &amp;gt;42\u202fs (\n                    <jats:italic>n<\/jats:italic>\n                    \u202f=\u202f19). A U-shaped relationship was observed between APTT and septic shock risk. Compared to the reference group (APTT 28\u201342\u202fs), the group with APTT &amp;gt;42\u202fs had a higher incidence of septic shock (57.9% vs. 11.8%), with a multivariable-adjusted odds ratio (OR) of 3.85 (95% CI, 0.94\u201315.78,\n                    <jats:italic>p<\/jats:italic>\n                    =\u202f0.061). APTT &amp;lt;28\u202fs was also associated with increased risk (adjusted OR 1.5; 95% CI, 1.02\u20132.2;\n                    <jats:italic>p<\/jats:italic>\n                    =\u202f0.04). Threshold analysis identified 27.564\u202fs as a critical point. In addition, each 1-s increase in APTT raised shock risk by 8.7%. Monitoring APTT may facilitate risk assessment in obstetric sepsis.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2026.1747286","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T06:32:20Z","timestamp":1768890740000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between activated partial thromboplastin time and septic shock in pregnant women: a retrospective cohort study"],"prefix":"10.3389","volume":"13","author":[{"given":"Shengjia","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dunjin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University","place":["Guangzhou, China"]},{"name":"Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital of Guangzhou Medical University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanmei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.bpa.2022.03.003","article-title":"Maternal sepsis","volume":"36","author":"Filetici","year":"2022","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"ref2","volume-title":"Global Burden of Maternal Sepsis in the Year 2000","author":"Dolea","year":"2003"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s12978-017-0437-8","article-title":"The global maternal sepsis study and awareness campaign (GLOSS): study protocol","volume":"15","author":"Bonet","year":"2018","journal-title":"Reprod 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