{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T16:16:21Z","timestamp":1770048981983,"version":"3.49.0"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aims to report the successful conservative management of herpes simplex keratitis (HSK) complicated by corneal perforation and anterior chamber collapse, emphasizing the importance of accurate diagnosis and close clinical monitoring to avoid surgical intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 54-year-old male patient with recurrent redness and pain in the left eye was referred for potential surgical intervention due to corneal perforation and anterior chamber collapse. Examination revealed central corneal infiltrates, a positive Seidel test, and anterior chamber collapse. A tear specimen was collected for polymerase chain reaction (PCR) testing to detect viruses, including herpes simplex virus (HSV), varicella zoster virus (VZV), cytomegalovirus (CMV), human adenovirus (HAdV), and Epstein\u2013Barr virus (EBV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PCR testing confirmed herpes simplex virus infection in this patient. Treatment with oral valacyclovir, topical ofloxacin ointment, and 0.1% fluorometholone eye drops resulted in significant clinical improvement. Over the course of 1 month, visual acuity improved from counting fingers at 80\u202fcm to 20\/30, corneal lesions healed, and the anterior chamber reformed without the need for surgical intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case demonstrates that conservative management can be effective for HSK with corneal perforation and anterior chamber collapse, particularly when supported by accurate diagnosis and close clinical monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1749225","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T05:15:34Z","timestamp":1770009334000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Conservative management of herpes simplex keratitis with corneal perforation and anterior chamber collapse"],"prefix":"10.3389","volume":"13","author":[{"given":"Wenjia","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine","place":["Hangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine","place":["Hangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luyi","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine","place":["Hangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1097\/ICL.0000000000000952","article-title":"The impact of antiviral resistance on herpetic keratitis","volume":"49","author":"Moshirfar","year":"2023","journal-title":"Eye Contact Lens"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1007\/s10792-018-0854-x","article-title":"Corneal perforation after noncontact tonometry in patients with active recurrent herpes simplex keratitis: case report","volume":"39","author":"Tananuvat","year":"2019","journal-title":"Int Ophthalmol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e22146","DOI":"10.1016\/j.heliyon.2023.e22146","article-title":"Highly sensitive and naked-eye detection of herpes simplex virus type 1 using LAMP- CRISPR\/Cas12 diagnostic technology and gold nanoparticles","volume":"9","author":"Huang","year":"2023","journal-title":"Heliyon"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1111\/opo.12859","article-title":"Clinical outcomes of herpes simplex keratitis: two-year experience from a quaternary eye care Centre in Sydney, Australia","volume":"41","author":"Cabrera-Aguas","year":"2021","journal-title":"Ophthalmic Physiol Opt"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.ajo.2011.07.020","article-title":"Long-term comparison of full-bed deep lamellar keratoplasty with penetrating keratoplasty in treating corneal leucoma caused by herpes simplex keratitis","volume":"153","author":"Wu","year":"2012","journal-title":"Am J Ophthalmol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1136\/bjo.87.5.543","article-title":"Therapeutic penetrating keratoplasty in severe fungal keratitis using cryopreserved donor corneas","volume":"87","author":"Yao","year":"2003","journal-title":"Br J Ophthalmol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1097\/ICO.0000000000003638","article-title":"Frequency and outcome of emergency penetrating keratoplasty in infectious keratitis in Sweden during the 21st century","volume":"44","author":"Viberg","year":"2025","journal-title":"Cornea"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1001\/archopht.1992.01080220054021","article-title":"The collaborative corneal transplantation studies (CCTS). 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