{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T06:18:34Z","timestamp":1771395514933,"version":"3.50.1"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic obstructive pulmonary disease (COPD) is frequently complicated by pulmonary hypertension (PH), which worsens prognosis, but early PH detection is limited by the invasiveness or suboptimal sensitivity of current diagnostic tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study, we analyzed 523 hospitalized patients with COPD from Beijing Chaoyang Hospital. After standardized preprocessing and recursive feature elimination, 18 routinely available noninvasive clinical and physiological variables were retained as predictors. Eight machine-learning algorithms were trained to predict PH and compared using area under the receiver operating characteristic curve (AUC), accuracy, sensitivity, specificity, F1 score, and decision-curve analysis; model interpretability was assessed with Shapley additive explanations (SHAP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The CatBoost model showed the best discrimination (AUC 0.848; accuracy 0.830; sensitivity 0.758; specificity 0.866; F1 0.746). SHAP analysis identified right ventricular diameter, pulmonary artery diameter, arterial partial pressure of carbon dioxide, right atrial transverse diameter, and age as the most influential predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A CatBoost-based prediction model using readily obtainable noninvasive variables can estimate PH risk in COPD with good accuracy and provide transparent feature-level explanations, potentially facilitating earlier detection and risk-stratified management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1752113","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T05:34:02Z","timestamp":1771392842000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and internal validation of a machine learning\u2013based prediction model for pulmonary hypertension in COPD"],"prefix":"10.3389","volume":"13","author":[{"given":"Ruoyu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Tan","sequence":"additional","affiliation":[{"name":"School of Information Engineering, Guangdong University of Technology","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangping","family":"Li","sequence":"additional","affiliation":[{"name":"School of Information Engineering, Guangdong University of Technology","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyu","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiling","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.2147\/COPD.S211841","article-title":"Updated perspectives on pulmonary hypertension in COPD","volume":"15","author":"Blanco","year":"2020","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1002\/cce2.71","article-title":"Classification and pathophysiology of pulmonary hypertension","volume":"4","author":"Sysol","year":"2018","journal-title":"Contin Cardiol Educ"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1016\/S2213-2600(23)00259-X","article-title":"Pulmonary hypertension associated with lung disease: new insights into pathomechanisms, diagnosis, and management","volume":"11","author":"Olsson","year":"2023","journal-title":"Lancet Respir 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