{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:57:32Z","timestamp":1789750652345,"version":"4.0.1"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to systematically evaluate the independent efficacy of platelet-rich fibrin (PRF) as a sole grafting material in alveolar ridge preservation and to dynamically delineate the trajectory of PRF\u2019s effects on alveolar ridge morphology and new bone formation across various healing stages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive search was conducted across four databases (PubMed, Embase, the Cochrane Library, and Web of Science) for pertinent records from their establishment until November 2025. The study encompassed randomized controlled trials (RCTs) that evaluated alveolar ridge preservation utilizing PRF alone in comparison to spontaneous healing. Two investigators independently conducted literature screening, data extraction, and methodological quality evaluation, employing the Cochrane Risk of Bias instrument (ROB-2) for the latter. The certainty of the evidence for each outcome was assessed using the GRADE framework. The meta-analysis utilized RevMan version 5.3, while publication bias was evaluated by Egger\u2019s test in Stata 18.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of eighteen studies were incorporated into the analysis. Compared to the spontaneous healing group, the PRF group showed significantly smaller losses in alveolar bone height at 3\u202fmonths (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.004; 95% CI\u202f=\u202f\u22121.59 to \u22120.31), 4\u202fmonths (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.002; 95% CI\u202f=\u202f\u22120.93 to \u22120.20), and 6\u202fmonths (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.03; 95% CI\u202f=\u202f\u22120.53 to \u22120.03). The use of PRF resulted in a significantly lower reduction in alveolar bone width at 2\u202fmonths (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.03; 95% CI\u202f=\u202f\u22121.18 to \u22120.05) and 3\u202fmonths. The percentage of new bone formation in the PRF group was significantly greater than that in the spontaneous healing group at both 3\u202fmonths (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.0008; 95% CI: 4.70\u201318.02) and 4\u202fmonths (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.010; 95% CI: 4.14\u201329.81). High-speed centrifugation was associated with significantly greater new bone formation than standard protocols (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.02), while effects on dimensional preservation did not differ significantly between protocols.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PRF appears to mitigate alveolar bone resorption following tooth extraction and may enhance new bone formation during the healing process. The osteogenic effect of PRF may be optimized by high-speed centrifugation protocols. As a secure autologous biomaterial, it is a promising option for preserving alveolar bone and enhancing circumstances for eventual implant restoration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/www.crd.york.ac.uk\/PROSPERO\/view\/CRD420251183872<\/jats:ext-link>\n                      , identifier PROSPERO (CRD420251183872).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1753189","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T05:24:03Z","timestamp":1771478643000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["The efficacy of platelet-rich fibrin in alveolar ridge preservation: a systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.3389","volume":"13","author":[{"given":"Jiahui","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Dentistry, The Second Affiliated Hospital of Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Dentistry, The Second Affiliated Hospital of Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/0022-3913(67)90046-7","article-title":"Alveolar ridge resorption following tooth extraction","volume":"17","author":"Pietrokovski","year":"1967","journal-title":"J Prosthet Dent"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.prosdent.2003.10.022","article-title":"Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study","volume":"23","author":"Schropp","year":"2003","journal-title":"Int J Periodontics Restorative Dent"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1600-0501.2011.02375.x","article-title":"A systematic review of post-extractional alveolar hard and soft tissue dimensional changes in humans","volume":"23","author":"Tan","year":"2012","journal-title":"Clin Oral Implants Res"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1111\/j.1600-0501.2011.02370.x","article-title":"Evidence-based knowledge on the biology and treatment of extraction sockets","author":"H\u00e4mmerle","year":"2012","journal-title":"Clin Oral Implants Res"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1177\/0022034514541127","article-title":"Effect of alveolar ridge preservation after tooth extraction: a systematic review and meta-analysis","volume":"93","author":"Avila-Ortiz","year":"2014","journal-title":"J Dent Res"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e37","DOI":"10.1016\/j.tripleo.2005.07.008","article-title":"Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution","volume":"101","author":"Dohan","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1007\/s00784-017-2133-z","article-title":"Use of platelet-rich fibrin in regenerative dentistry: a systematic review","volume":"21","author":"Miron","year":"2017","journal-title":"Clin Oral Investig"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"310","DOI":"10.2741\/4593","article-title":"Growth factors in the pathogenesis of diabetic foot ulcers","volume":"23","author":"Qi","year":"2018","journal-title":"Front Biosci (Landmark Ed)"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"4948139","DOI":"10.1155\/2021\/4948139","article-title":"The role of platelet-rich fibrin (PRF) in the prevention of medication-related osteonecrosis of the jaw (MRONJ)","volume":"2021","author":"Miranda","year":"2021","journal-title":"Biomed Res 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