{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:04:30Z","timestamp":1787321070919,"version":"build-2736575974"},"reference-count":12,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Early sepsis bundle therapy serves as the cornerstone in the management of sepsis, yet the optimal time targets for its administration remain unclear. We quantified the time interval for the use of bundled therapy and assessed the association between the delay in initiating bundled therapy and in-hospital mortality among patients with suspected sepsis treated in the ED.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Patients with sepsis were collected retrospectively from January 2019 to December 2024, and we divided the sepsis bundle therapy time into two intervals: ED to sepsis bundle orders (recognition delay) and sepsis bundle orders to sepsis bundle implementation (treatment delay). Subsequent statistical analyses were conducted to evaluate the correlations between these two time intervals and patient prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After adjusting for confounding factors, the two time intervals were associated with the mortality rate during hospitalization, but this association was observed in longer delays compared to the no-delay control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The timing of initiating sepsis bundle therapy should be highlighted by medical professionals, and additional investigations are required to refine the optimal timing for the clinical implementation of bundle therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1756833","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T05:35:13Z","timestamp":1786426513000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The relationship between sepsis bundle delay intervals and in-hospital mortality of sepsis patients in ICU"],"prefix":"10.3389","volume":"13","author":[{"given":"Chenhong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Emergency, Anqing Medical Center, Anhui Medical University","place":["Anqing, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Emergency, Anqing Medical Center, Anhui Medical University","place":["Anqing, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosheng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Emergency, Anqing Medical Center, Anhui Medical University","place":["Anqing, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Emergency, Anqing Medical Center, Anhui Medical University","place":["Anqing, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Emergency, Anqing Medical Center, Anhui Medical University","place":["Anqing, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuming","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Emergency, Anqing Medical Center, Anhui Medical University","place":["Anqing, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linfeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Emergency, Anqing Medical Center, Anhui Medical University","place":["Anqing, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Emergency, Anqing Medical Center, Anhui Medical University","place":["Anqing, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoqing","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Emergency, Anqing Medical Center, Anhui Medical University","place":["Anqing, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e27560","DOI":"10.1016\/j.heliyon.2024.e27560","article-title":"The relationship between lactate dehydrogenase to albumin ratio and all-cause mortality during ICU stays in patients with sepsis: a retrospective cohort study with propensity score matching","volume":"10","author":"Guan","year":"2024","journal-title":"Heliyon"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1007\/s00134-018-5085-0","article-title":"The surviving sepsis campaign bundle: 2018 update","volume":"44","author":"Levy","year":"2018","journal-title":"Intensive Care Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1164\/rccm.201609-1848OC","article-title":"The timing of early antibiotics and hospital mortality in sepsis","volume":"196","author":"Liu","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1097\/01.CCM.0000217961.75225.E9","article-title":"Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock","volume":"34","author":"Kumar","year":"2006","journal-title":"Crit Care Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1056\/NEJMoa1703058","article-title":"Time to treatment and mortality during mandated emergency care for sepsis","volume":"376","author":"Seymour","year":"2017","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1097\/CCM.0000000000005357","article-title":"Executive summary: surviving sepsis campaign: international guidelines for the management of sepsis and septic shock 2021","volume":"49","author":"Evans","year":"2021","journal-title":"Crit Care Med"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1097\/CCM.0000000000003613","article-title":"National performance on the medicare SEP-1 sepsis quality measure","volume":"47","author":"Barbash","year":"2019","journal-title":"Crit Care Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1164\/rccm.202112-2743OC","article-title":"Epidemiology, management, and outcomes of sepsis in ICUs among countries of differing National Wealth across Asia","volume":"206","author":"Li","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.chest.2018.10.008","article-title":"POINT: should the surviving sepsis campaign guidelines be retired?","volume":"155","author":"Marik","year":"2019","journal-title":"Yes Chest"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1186\/s12879-019-4618-7","article-title":"Diagnostic and prognostic value of interleukin-6, pentraxin 3, and procalcitonin levels among sepsis and septic shock patients: a prospective controlled study according to the Sepsis-3 definitions","volume":"19","author":"Song","year":"2019","journal-title":"BMC Infect Dis"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"185","DOI":"10.5811\/westjem.2018.11.39290","article-title":"Challenging the one-hour sepsis bundle","volume":"20","author":"Kalantari","year":"2019","journal-title":"West J Emerg Med"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1007\/s00134-015-3906-y","article-title":"The surviving Sepsis campaign bundles and outcome: results from the international multicentre prevalence study on Sepsis (the IMPreSS study)","volume":"41","author":"Rhodes","year":"2015","journal-title":"Intensive Care Med"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1756833\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:03:31Z","timestamp":1787317411000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1756833\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,11]]},"references-count":12,"alternative-id":["10.3389\/fmed.2026.1756833"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1756833","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,11]]},"article-number":"1756833"}}