{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T09:47:52Z","timestamp":1774000072699,"version":"3.50.1"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>CD147 (Basigin\/EMMPRIN) is a widely expressed trans-membrane glycoprotein. While its role in tumorigenesis is well-established, its functions in the process of pregnancy remain to be systematically elucidated. This review summarizes the expression patterns and functional mechanisms of CD147 in both normal and pathological pregnancies. During normal pregnancy, CD147 plays a critical role in embryo implantation, placental development, and pregnancy maintenance by regulating the expression of matrix metalloproteinases (MMPs), promoting angiogenesis, participating in the construction of the maternal-fetal immune micro-environment, and modulating placental energy metabolism. In pathological pregnancies, aberrant CD147 expression is closely associated with various obstetric complications: its down-regulation is linked to pre-eclampsia, recurrent implantation failure, and fetal growth restriction, whereas its up-regulation may promote invasive behaviors in gestational choriocarcinoma and placenta accreta spectrum. This review emphasizes the \u201cdual regulatory\u201d characteristic of CD147 in pregnancy, highlighting its potential as a biomarker and therapeutic target, and proposes directions for future research.<\/jats:p>","DOI":"10.3389\/fmed.2026.1757302","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T06:37:09Z","timestamp":1773988629000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["CD147: a critical factor in normal and pathological pregnancies"],"prefix":"10.3389","volume":"13","author":[{"given":"Hangyu","family":"Sun","sequence":"first","affiliation":[{"name":"Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases","place":["Shanghai, 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