{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T02:36:17Z","timestamp":1793500577478,"version":"4.5.0"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    This case report describes a 51-year-old female patient who presented with dyspnea and was diagnosed with invasive aspergillosis affecting the pericardium and lungs, secondary to immunodeficiency syndrome caused by anti-interferon-\u03b3 autoantibodies. Diagnosis was established by pericardial tissue metagenomic next-generation sequencing (mNGS) identifying\n                    <jats:italic>Aspergillus udagawae<\/jats:italic>\n                    and serum anti-interferon-\u03b3 autoantibody testing (titer 1:2,500). Despite sequential antifungal therapy with voriconazole, isavuconazole, and amphotericin B, the patient developed progressive multifocal infection, including an abdominal wall abscess and mediastinal infection caused by\n                    <jats:italic>Aspergillus siamensis<\/jats:italic>\n                    , and ultimately died of multiple organ failure. This case highlights the diagnostic challenges and poor prognosis associated with this rare immunodeficiency syndrome and emphasizes the importance of early recognition, precise pathogen identification, and consideration of immunomodulatory therapy.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2026.1760017","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T05:25:29Z","timestamp":1776317129000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Invasive pericardial and pulmonary aspergillosis by uncommon Aspergillus species in anti-interferon-\u03b3 autoantibody-associated immunodeficiency: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Junyuan","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Liuzhou People's Hospital Affiliated to Guangxi Medical University (Key Laboratory of Asthma and Chronic Obstructive Pulmonary Disease Diagnosis, Treatment and Research, Liuzhou)","place":["Liuzhou, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijuan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Liuzhou People's Hospital Affiliated to Guangxi Medical University (Key Laboratory of Asthma and Chronic Obstructive Pulmonary Disease Diagnosis, Treatment and Research, Liuzhou)","place":["Liuzhou, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Liuzhou People's Hospital Affiliated to Guangxi Medical University (Key Laboratory of Asthma and Chronic Obstructive Pulmonary Disease Diagnosis, Treatment and Research, Liuzhou)","place":["Liuzhou, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Liuzhou People's Hospital Affiliated to Guangxi Medical University (Key Laboratory of Asthma and Chronic Obstructive Pulmonary Disease Diagnosis, Treatment and Research, Liuzhou)","place":["Liuzhou, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunying","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Liuzhou People's Hospital Affiliated to Guangxi Medical University (Key Laboratory of Asthma and Chronic Obstructive Pulmonary Disease Diagnosis, Treatment and Research, Liuzhou)","place":["Liuzhou, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guixin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Liuzhou People's Hospital Affiliated to Guangxi Medical University (Key Laboratory of Asthma and Chronic Obstructive Pulmonary Disease Diagnosis, Treatment and Research, Liuzhou)","place":["Liuzhou, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Liuzhou People's Hospital Affiliated to Guangxi Medical University (Key Laboratory of Asthma and Chronic Obstructive Pulmonary Disease Diagnosis, Treatment and Research, Liuzhou)","place":["Liuzhou, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Liuzhou People's Hospital Affiliated to Guangxi Medical University (Key Laboratory of Asthma and Chronic Obstructive Pulmonary Disease Diagnosis, Treatment and Research, Liuzhou)","place":["Liuzhou, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejiao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Liuzhou People's Hospital Affiliated to Guangxi Medical University (Key Laboratory of Asthma and Chronic Obstructive Pulmonary Disease Diagnosis, Treatment and Research, Liuzhou)","place":["Liuzhou, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Liuzhou People's Hospital Affiliated to Guangxi Medical University (Key Laboratory of Asthma and Chronic Obstructive Pulmonary Disease Diagnosis, Treatment and Research, Liuzhou)","place":["Liuzhou, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e10","DOI":"10.1086\/380453","article-title":"Autoantibodies to interferon-gamma in a patient with selective susceptibility to mycobacterial infection and organ-specific autoimmunity","volume":"38","author":"D\u00f6ffinger","year":"2004","journal-title":"Clin Infect Dis"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1182\/blood-2003-04-1065","article-title":"Naturally occurring anti-Ifn-gamma autoantibody and severe infections with Mycobacterium cheloneae and Burkholderia cocovenenans","volume":"103","author":"H\u00f6flich","year":"2004","journal-title":"Blood"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1056\/nejmoa1111160","article-title":"Adult-onset immunodeficiency in Thailand and 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