{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:05:32Z","timestamp":1792811132075,"version":"4.5.0"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ovarian endometrioma is a common form of endometriosis associated with chronic pelvic pain, infertility, and diminished ovarian reserve. Although anti-M\u00fcllerian hormone (AMH) is widely used to evaluate ovarian reserve, it does not reflect structural ovarian changes. To introduce and assess the Ovary to Endometrioma Volume Index (OEVI), calculated from magnetic resonance imaging (MRI), as noninvasive marker of ovarian reserve in women with endometrioma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty women of reproductive age with ovarian endometrioma were included. Patients with menopause, primary ovarian failure, or prior endometrioma surgery were excluded. Serum AMH, follicle stimulating hormone (FSH), luteinizing hormone (LH), and cancer antigen 125 (Ca-125) were measured. Ovarian and endometrioma volumes were quantified on pelvic MRI, and OEVI was calculated as total ovarian volume divided by total endometrioma volume. Spearman correlation and multivariable regression analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      OEVI showed a positive correlation with AMH (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u202f=\u202f0.332) and negative correlations with FSH (\u03c1\u202f=\u202f\u22120.306) and LH (\u03c1\u202f=\u202f\u22120.422). In exploratory multivariable analysis, AMH showed a positive association with OEVI (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u202f=\u202f0.337,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.030), whereas Ca-125 (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u202f=\u202f\u22120.018,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.022) and LH (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u202f=\u202f\u22120.141,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.035) demonstrated inverse associations. The regression model explained 42% of OEVI variability. The regression model explained 42% of OEVI variability.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>OEVI demonstrates significant associations with established hormonal markers and may represent a promising structural adjunct in ovarian reserve assessment. Its association with AMH and inverse relationship with gonadotropins suggest that OEVI reflects both structural and functional ovarian capacity and may support individualized clinical management and fertility counseling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1760689","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T05:37:06Z","timestamp":1776145026000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["A novel magnetic resonance imaging index to evaluate ovarian reserve in endometrioma patients: the ovary to endometrioma volume index"],"prefix":"10.3389","volume":"13","author":[{"given":"Mesut","family":"\u00d6nal","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Ondokuz Mayis University","place":["Samsun, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adem","family":"Kocaman","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, Ondokuz Mayis University","place":["Samsun, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunus","family":"Kat\u0131rc\u0131","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Ondokuz Mayis University","place":["Samsun, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lkay","family":"\u00c7aml\u0131da\u011f","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, Ondokuz Mayis University","place":["Samsun, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fcseyin","family":"Ekici","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Ondokuz Mayis University","place":["Samsun, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abd\u00fclkadir","family":"Bakay","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Ondokuz Mayis University","place":["Samsun, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1097\/00003081-200609000-00008","article-title":"Management of ovarian endometrioma","volume":"49","author":"Alborzi","year":"2006","journal-title":"Clin Obstet Gynecol"},{"key":"ref2","volume-title":"StatPearls","author":"Hoyle","year":"2022"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/nrendo.2013.255","article-title":"Endometriosis: pathogenesis and 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as useful markers to distinguish malignant transformation from benign endometriotic cysts","volume-title":"Cancer Biomarkers","author":"Yoshimoto","year":"2015"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"808","DOI":"10.3109\/09513590.2014.938625","article-title":"Increased oxidative and carbonyl stress markers in ovarian cortex of women with endometrioma","volume":"30","author":"Di Emidio","year":"2014","journal-title":"Gynecol Endocrinol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"2140","DOI":"10.1093\/humrep\/det123","article-title":"Prospective assessment of the impact of endometriomas and their removal on ovarian reserve","volume":"28","author":"Uncu","year":"2013","journal-title":"Hum Reprod"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.fertnstert.2018.03.015","article-title":"Endometrioma-related reduction in ovarian reserve (ERROR): a prospective longitudinal 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