{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T21:23:27Z","timestamp":1768512207154,"version":"3.49.0"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) is a rare mitochondrial disorder primarily presenting with neurological manifestations, but it may also lead to gastrointestinal complications such as intestinal pseudo-obstruction, which can significantly complicate clinical management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report a 24-year-old woman with genetically confirmed MELAS (mtDNA A3243G mutation and TRPM3 c.2878G\u202f&amp;gt;\u202fT heterozygous variant) who was admitted with acute confusion and generalized convulsive seizures. Neuroimaging revealed multiple low-density lesions on CT and abnormal signals in the bilateral occipital lobes and basal ganglia on MRI. Although her neurological symptoms stabilized after emergency treatment, she subsequently developed recurrent episodes of intestinal obstruction characterized by vomiting and decreased bowel sounds. Conservative measures were unsuccessful, and jejunal decompression was performed, resulting in significant improvement in bowel function and successful transition to normal oral intake.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case illustrates delayed acute intestinal pseudo-obstruction (AIPO) as an uncommon but clinically important complication of MELAS, and shows that timely jejunal decompression can be an effective therapeutic intervention in selected patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1760790","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T06:28:11Z","timestamp":1768458491000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A case of delayed acute intestinal pseudo-obstruction after MELAS crisis in mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes"],"prefix":"10.3389","volume":"13","author":[{"given":"Qinggen","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery, Jinan Zhangqiu District People\u2019s Hospital","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jinan Zhangqiu District People\u2019s Hospital","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengcheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jinan Zhangqiu District People\u2019s Hospital","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xipeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thyroid and Breast Surgery, Jinan Zhangqiu District People\u2019s Hospital","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiyue","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jinan Zhangqiu District People\u2019s Hospital","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Jinan Zhangqiu District People\u2019s Hospital","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Jinan Zhangqiu District People\u2019s Hospital","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-025-03985-4","article-title":"Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) patients with m.3243A\u202f>\u202fG have high prevalence of Wolff-Parkinson-white syndrome","author":"Liu","year":"2025","journal-title":"Pediatr Cardiol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"511","DOI":"10.11817\/j.issn.1672-7347.2025.240250","article-title":"A case of mitochondrial encephalomyopathy remarkable presenting with refractory shock","volume":"50","author":"Liao","year":"2025","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"464","DOI":"10.5692\/clinicalneurol.cn-001694","article-title":"A case of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like 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