{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T17:09:57Z","timestamp":1771520997050,"version":"3.50.1"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2024-22-6"],"award-info":[{"award-number":["320.6750.2024-22-6"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinical Research Enhancement Project of Beijing Chaoyang Hospital","award":["CYTS2025A03"],"award-info":[{"award-number":["CYTS2025A03"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Fulminant amebic colitis complicated by intestinal perforation or massive intra-abdominal hemorrhage is uncommon but associated with extremely high mortality. In non-endemic regions, diagnosis is frequently delayed because early manifestations resemble bacterial appendicitis or perforated peritonitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>\n                      We report a fatal case of\n                      <jats:italic>Entamoeba histolytica<\/jats:italic>\n                      infection presenting with appendiceal perforation, septic shock, and recurrent intra-abdominal bleeding. Surgery revealed extensive transmural necrosis, deep ulcers, and exposure of submucosal vessels. Metagenomic next-generation sequencing (mNGS) of blood and peritoneal drainage fluid was performed, followed by histopathological confirmation. Despite emergent appendectomy, bowel resection, and prompt initiation of anti-amebic therapy, the patient developed refractory septic shock and recurrent intra-abdominal hemorrhage, resulting in death.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>mNGS can facilitate early recognition of severe amebiasis when conventional diagnostic modalities are uncertain, particularly in non-endemic settings. Fulminant amebic colitis complicated by perforation or hemorrhage carries a poor prognosis. Timely clinical suspicion and early anti-amebic therapy are essential to improve outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1760895","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T16:22:10Z","timestamp":1771518130000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Fulminant amebic colitis complicated by appendiceal perforation and massive abdominal hemorrhage: a case report and literature review"],"prefix":"10.3389","volume":"13","author":[{"given":"Xin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxiong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenliang","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoyang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youwei","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guichen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimiao","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuyan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University","place":["Beijing, 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