{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T07:10:21Z","timestamp":1771571421282,"version":"3.50.1"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"\n Background<\/jats:title>\n To systematically evaluate the efficacy of Cangfu Daotan decoction combined with Diane-35 in treating phlegm-dampness polycystic ovary syndrome (PCOS) and its effects on endocrine- and metabolism-related outcomes.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Major English and Chinese databases (PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang, CQVIP, and SinoMed) were searched. Randomized controlled trials comparing Cangfu Daotan-based therapy plus Diane-35 versus Diane-35-based regimens were included. Two reviewers independently screened studies, extracted data, and assessed the risk of bias via the Cochrane tool. The meta-analysis was conducted with RevMan 5.4. The relative risk (RR) with 95% confidence intervals (CIs) was used for dichotomous outcomes, and the mean difference (MD) with 95% CIs was used for continuous outcomes. Fixed- or random-effects models were applied according to heterogeneity (\n I<\/jats:italic>\n 2<\/jats:sup>\n threshold of 50%). Publication bias was assessed via funnel plots.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Sixteen trials were included. Compared with the controls, the combination therapy significantly improved the total effective rate (RR\u202f=\u202f1.24, 95% CI 1.18\u20131.31,\n p<\/jats:italic>\n \u202f&lt;\u202f0.00001). It also significantly reduced serum testosterone (MD\u202f=\u202f\u22120.26, 95% CI \u20130.37 to \u22120.15, p\u202f&lt;\u202f0.00001), luteinizing hormone (MD\u202f=\u202f\u22121.64, 95% CI \u20132.46 to \u22120.82,\n p<\/jats:italic>\n \u202f&lt;\u202f0.0001), follicle-stimulating hormone (MD\u202f=\u202f\u22120.62, 95% CI \u20131.11 to \u22120.13,\n p<\/jats:italic>\n \u202f=\u202f0.01), and the LH\/FSH ratio (MD\u202f=\u202f\u22120.27, 95% CI \u20130.43 to \u22120.12,\n p<\/jats:italic>\n \u202f=\u202f0.0006). BMI also decreased (MD\u202f=\u202f\u22121.55, 95% CI \u20133.06 to \u22120.04,\n p<\/jats:italic>\n \u202f=\u202f0.04). Funnel plots suggested no obvious publication bias. Overall risk-of-bias assessment indicated insufficient reporting or implementation of blinding and unclear allocation concealment.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Cangfu Daotan decoction combined with Diane-35 may enhance clinical efficacy and improve key hormonal indicators and BMI in patients with phlegm-dampness-related PCOS. However, the evidence is limited by methodological weaknesses and heterogeneity across studies; well-designed, large-scale RCTs are needed to confirm these findings.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fmed.2026.1761111","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T06:42:37Z","timestamp":1771569757000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cangfu Daotan decoction with Diane-35 in phlegm-dampness polycystic ovary syndrome: a meta-analysis and systematic review"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiaomeng","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hangzhou Women\u2019s Hospital (Hangzhou Maternity and Child Health Care Hospital)","place":["Hangzhou, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hangzhou Women\u2019s Hospital (Hangzhou Maternity and Child Health Care Hospital)","place":["Hangzhou, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2841","DOI":"10.1093\/humrep\/dew218","article-title":"The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis","volume":"31","author":"Bozdag","year":"2016","journal-title":"Hum Reprod"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1056\/NEJMoa1313517","article-title":"Letrozole versus clomiphene for infertility in the polycystic ovary syndrome","volume":"371","author":"Legro","year":"2014","journal-title":"N Engl J 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Drug Use"},{"key":"ref38","first-page":"2545","article-title":"Efficacy of modified Cangfu Daotan decoction combined with metformin and ethinylestradiol\u2013cyproterone acetate tablets in treating phlegm-dampness type polycystic ovary syndrome and its effect on serum ghrelin","volume":"39","author":"Dong","year":"2022","journal-title":"Journal of Guangzhou University of Traditional Chinese Medicine"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1761111\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T06:42:42Z","timestamp":1771569762000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1761111\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,20]]},"references-count":38,"alternative-id":["10.3389\/fmed.2026.1761111"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1761111","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,20]]},"article-number":"1761111"}}