{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:39:41Z","timestamp":1791578381924,"version":"4.3.4"},"reference-count":180,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    Curcumin, a bioactive polyphenol derived from turmeric (\n                    <jats:italic>Curcuma longa<\/jats:italic>\n                    ), has garnered substantial attention for its potent anti-inflammatory, antioxidant, and antineoplastic properties. This review explores the therapeutic potential of curcumin in gynecologic health, with a focus on its role in the management of ovarian, cervical, and endometrial cancers, as well as benign conditions such as endometriosis, polycystic ovary syndrome, premenstrual syndrome, and menopausal symptoms. A literature review was conducted on the health effects of gynecology. Relevant articles were identified through systematic searches in major biomedical databases, including PubMed, Scopus, Cochrane Library, Embase, and Web of Science databases for studies reporting the relationship between curcumin and some in gynecological diseasess as of 2025. Curcumin modulates key inflammatory signaling pathways, reduces oxidative stress, and exerts antiproliferative effects, making it a promising adjunct in the treatment of both neoplastic and inflammatory gynecologic disorders. Nevertheless, clinical translation remains limited by challenges such as poor bioavailability and a paucity of large-scale, randomized controlled trials. Emerging evidence supports the integration of curcumin into multimodal treatment strategies, particularly in oncology and chronic inflammatory conditions. In light of the need to improve treatment efficacy and enhance patients\u2019 quality of life, the exploration of novel adjuvant therapeutic strategies is highly warranted. Recent studies have demonstrated the beneficial effects of curcumin and its novel analogues across a range of gynecologic diseases, while advances in formulation technologies have led to improved pharmacokinetic profiles and therapeutic outcomes. Nevertheless, further robust clinical investigations are required to optimize curcumin formulations, enhance bioavailability, and establish evidence-based guidelines for its integration into gynecologic care. This review synthesizes current evidence and highlights the underlying molecular mechanisms responsible for the observed effects, aiming to support the rational development of curcumin-based strategies in gynecology.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2026.1761721","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T06:42:09Z","timestamp":1771569729000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["From bench to bedside: unlocking the anti-inflammatory, antioxidant, and anticancer promise of curcumin in gynecology"],"prefix":"10.3389","volume":"13","author":[{"given":"Nazl\u0131 Tunca","family":"Sanlier","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ni\u011fde \u00c7iflik State Hospital","place":["Ni\u011fde, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koray Gorkem","family":"Sacinti","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Obstetrics and Gynecology, Yale School of Medicine","place":["New Haven, CT, United States"]},{"name":"Department of Epidemiology, Hacettepe University Faculty of Medicine","place":["Ankara, T\u00fcrkiye"]},{"name":"Department of Public Health, Hacettepe University Faculty of Medicine","place":["Ankara, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130nci","family":"Turkoglu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Hacettepe University Faculty of Health Sciences","place":["Ankara, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevin","family":"Sanlier","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, School of Health Sciences, Ankara Medipol University","place":["Ankara, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"322","DOI":"10.3390\/antibiotics11030322","article-title":"Antimicrobial potential of curcumin: therapeutic potential and challenges to clinical applications.","volume":"11","author":"Hussain","year":"2022","journal-title":"Antibiotics"},{"key":"B2","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1002\/biof.1344","article-title":"Curcumin as a multifaceted compound against human papilloma virus infection and cervical cancers: a review of chemistry, cellular, molecular, and preclinical features.","volume":"43","author":"Teymouri","year":"2017","journal-title":"Biofactors."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1040259","DOI":"10.3389\/fnut.2022.1040259","article-title":"Impacts of turmeric and its principal bioactive curcumin on human health: pharmaceutical, medicinal, and food applications: a comprehensive review.","volume":"9","author":"El-Saadony","year":"2023","journal-title":"Front Nutr."},{"key":"B4","doi-asserted-by":"publisher","first-page":"4794","DOI":"10.3390\/molecules26164794","article-title":"Curcumin as prospective anti-aging natural compound: focus on brain.","volume":"26","author":"Benameur","year":"2021","journal-title":"Molecules."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2580","DOI":"10.3390\/cancers16142580","article-title":"The bright side of curcumin: a narrative review of its therapeutic potential in cancer management.","volume":"16","author":"Amaroli","year":"2024","journal-title":"Cancers."},{"key":"B6","doi-asserted-by":"publisher","first-page":"133","DOI":"10.3390\/antiox13010133","article-title":"A critical appraisal of the protective activity of polyphenolic antioxidants against iatrogenic effects of anticancer chemotherapeutics.","volume":"13","author":"Purgatorio","year":"2024","journal-title":"Antioxidants."},{"key":"B7","doi-asserted-by":"publisher","first-page":"530","DOI":"10.3389\/fphar.2018.00530","article-title":"Anticancer activity and mechanism of Xanthohumol: a prenylated flavonoid from hops (Humulus lupulus L.).","volume":"9","author":"Jiang","year":"2018","journal-title":"Front Pharmacol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/B978-0-12-815461-8.00002-5","article-title":"Curcumin: historical background, chemistry, pharmacological action, and potential therapeutic value.","author":"Farooqui","year":"2019","journal-title":"Curcum. 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