{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T06:46:58Z","timestamp":1776235618148,"version":"3.50.1"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"State Key Laboratory of Ultrasound Engineering in Medicine","award":["2020KFKT002"],"award-info":[{"award-number":["2020KFKT002"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Laparoscopic lateral suspension (LLS) is a novel technique for repairing anterior and apical pelvic organ prolapse (POP). However, the efficacy is limited for advanced apical defects, particularly when combined with posterior compartment prolapse. This preliminary study evaluated the short-term outcomes of mesh-based LLS combined with uterosacral ligament suspension (USLS) for treating advanced apical prolapse with involvement of both the anterior and posterior compartments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between January 2022 and June 2024, 28 women with apical POP \u2265 stage III underwent mesh-based LLS with USLS. Titanized polypropylene mesh was placed on the vesicovaginal fascia, and the posterior compartment defects were addressed with USLS. All patients preserved their uterus. Clinical outcomes were assessed using the gynecological examination and the pelvic organ prolapse quantification (POP-Q) system. Objective anatomic success was defined as POP-Q stage &amp;lt;II at all points at 12-month follow-up. Subjective outcomes were measured with the Pelvic Floor Distress Inventory Questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age of participants was 57.71\u202f\u00b1\u202f10.36\u202fyears, with a mean BMI of 25.48\u202f\u00b1\u202f2.87\u202fkg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Concomitant procedures included distal posterior vaginal wall repair (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f16), partial cervical resection (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f5), hysteroscopy (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f9), and other procedures. No serious perioperative complications occurred in the patients. While anatomical restoration was high in this small cohort (100%), these results are preliminary. Subgroup analysis showed no significant difference in point Bp restoration between patients with and without distal vaginal repair (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;gt;\u202f0.05). No serious complications or mesh exposure occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Combining LLS with USLS is a safe and potentially effective treatment for advanced, multi-compartment apical prolapse in this preliminary cohort. While short-term outcomes are encouraging, the lack of a control group and the potential confounding effect of distal vaginal repair necessitate larger studies to confirm long-term durability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1763296","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T05:45:07Z","timestamp":1776231907000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Laparoscopic lateral suspension combined with uterosacral ligament suspension for advanced apical pelvic organ prolapse: preliminary outcomes of a retrospective series"],"prefix":"10.3389","volume":"13","author":[{"given":"Shuxu","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Gynecology, Qingdao Women and Children\u2019s Hospital, Qingdao University","place":["Qingdao, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenchen","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Qilu Hospital of Shandong University (Qingdao)","place":["Qingdao, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Qingdao Women and Children\u2019s Hospital, Qingdao University","place":["Qingdao, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Qingdao Women and Children\u2019s Hospital, Qingdao University","place":["Qingdao, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huangbei","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Qingdao Women and Children\u2019s Hospital, Qingdao University","place":["Qingdao, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuping","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Qingdao Women and Children\u2019s Hospital, Qingdao University","place":["Qingdao, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"CD012376","DOI":"10.1002\/14651858.CD012376","article-title":"Surgery for women with apical vaginal prolapse","volume":"10","author":"Maher","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1097\/01.AOG.0000139514.90897.07","article-title":"Abdominal sacrocolpopexy: a comprehensive review","volume":"104","author":"Nygaard","year":"2004","journal-title":"Obstet Gynecol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s00192-021-04784-0","article-title":"Laparoscopic lateral suspension for anterior and apical prolapse: a prospective cohort with standardized technique","volume":"33","author":"Chatziioannidou","year":"2022","journal-title":"Int Urogynecol J"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"898392","DOI":"10.3389\/fsurg.2022.898392","article-title":"Laparoscopic lateral suspension (LLS) for the treatment of apical prolapse: a new gold standard?","volume":"9","author":"Dallenbach","year":"2022","journal-title":"Front Surg"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.gyobfe.2010.12.007","article-title":"Laparoscopic repair of pelvic organ prolapse by lateral suspension with mesh: a continuous series of 218 patients","volume":"39","author":"Dubuisson","year":"2011","journal-title":"Gynecol Obstet Fertil"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.ejogrb.2019.10.026","article-title":"Laparoscopic lateral suspension with mesh for apical and anterior pelvic organ prolapse: a prospective double center study","volume":"244","author":"Mereu","year":"2020","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"3056","DOI":"10.3390\/jcm14093056","article-title":"Laparoscopic lateral suspension (LLS) for pelvic organ prolapse (POP): update and systematic review of prospective and randomised trials","volume":"14","author":"Plotti","year":"2025","journal-title":"J Clin Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s00192-021-04826-7","article-title":"The distribution of pelvic organ support defects in women undergoing pelvic organ prolapse surgery and compartment specific risk factors","volume":"33","author":"Payebto Zoua","year":"2022","journal-title":"Int Urogynecol J"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1002\/nau.24115","article-title":"Comparison of laparoscopic techniques for apical organ prolapse repair\u2014a systematic review of the literature","volume":"38","author":"Szymczak","year":"2019","journal-title":"Neurourol Urodyn"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1111\/1471-0528.17565","article-title":"The effectiveness and safety of laparoscopic uterosacral ligament suspension: a systematic review and meta-analysis","volume":"130","author":"Vermeulen","year":"2023","journal-title":"BJOG"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1016\/j.eururo.2013.12.064","article-title":"A review of the current status of laparoscopic and robot-assisted sacrocolpopexy for pelvic organ prolapse","volume":"65","author":"Lee","year":"2014","journal-title":"Eur Urol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1001\/jama.2013.4919","article-title":"Long-term outcomes following abdominal sacrocolpopexy for pelvic organ prolapse","volume":"309","author":"Nygaard","year":"2013","journal-title":"JAMA"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1007\/s00192-008-0657-0","article-title":"Laparoscopic sacrocolpopexy for uterine and post-hysterectomy prolapse: anatomical results, quality of life and perioperative outcome-a prospective study with 101 cases","volume":"19","author":"Sarlos","year":"2008","journal-title":"Int Urogynecol J Pelvic Floor Dysfunct"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1007\/s00192-016-2974-z","article-title":"Incidence and risk factors for mesh erosion after laparoscopic repair of pelvic organ prolapse by lateral suspension with mesh","volume":"27","author":"Dallenbach","year":"2016","journal-title":"Int Urogynecol J"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s11701-021-01234-3","article-title":"Outcomes of robotically assisted laparoscopic lateral suspension (RALLS) with mesh for anterior and apical prolapse","volume":"16","author":"Dallenbach","year":"2022","journal-title":"J Robot Surg"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/j.jmig.2025.02.014","article-title":"Comparing the efficacy of laparoscopic pectopexy and laparoscopic sacrocolpopexy for pelvic organ prolapse: a systematic review and meta-analysis","volume":"32","author":"Parsaei","year":"2025","journal-title":"J Minim Invasive Gynecol"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1763296\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T05:45:08Z","timestamp":1776231908000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1763296\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,15]]},"references-count":16,"alternative-id":["10.3389\/fmed.2026.1763296"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1763296","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,15]]},"article-number":"1763296"}}