{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T06:11:41Z","timestamp":1777961501974,"version":"3.51.4"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Sarcopenia is a progressive and complex disorder associated with higher morbidity and mortality, which significantly increases the financial burden and medical costs. This study aims to investigate the relationship of the systemic inflammation response index (SIRI) and the systemic immune-inflammation index (SII) with proxy-assessed sarcopenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was a cross-sectional and observational study. The sociodemographic information, lifestyle habits, anthropometric measurements, disease history and medication history, and medical examination data of these individuals were collected. Multivariate logistic regression analyses were performed to estimate the odds ratio (ORs) and 95% confidence intervals (CIs) for proxy-assessed sarcopenia when adjusted for different confounders. Restricted cubic spline (RCS) regression model was used to model the association of SIRI or SII with the presence of proxy-assessed sarcopenia. Furthermore, the associations between SIRI or SII and proxy-assessed sarcopenia in different subgroups by grouping sex, age, metabolic dysfunction-associated steatotic liver disease (MASLD), current smoking, alcohol consumption, type 2 diabetes mellitus, hypertension, dyslipidemia were identified by multivariate logistic regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1706 community-dwelling older adults participated in this study, including 949 males and 757 females, with a median age of 72 years for the total population. In the multivariate logistic regression models, after adjusting for confounding factors, a statistically significant association with SIRI or SII and proxy-assessed sarcopenia was found. The RCS model showed that a positive association between SIRI and proxy-assessed sarcopenia, as well as SII and proxy-assessed sarcopenia, and the non-linear relationship between SIRI and proxy-assessed sarcopenia was statistically significant. Similar results were found in the association between SII and proxy-assessed sarcopenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, our study demonstrated a significant association of SIRI and SII with proxy-assessed sarcopenia in community-dwelling older adults, underscoring the relevance of systemic inflammation in proxy-assessed sarcopenia and supporting the potential value of these indices in future pathophysiological and longitudinal studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1764196","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T05:31:43Z","timestamp":1777959103000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations of systemic inflammation response index and systemic immune-inflammation index 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