{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:09:26Z","timestamp":1779253766044,"version":"3.51.4"},"reference-count":6,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Qingdao Medical and Health Research Project","award":["2025-WJKY090"],"award-info":[{"award-number":["2025-WJKY090"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To present three cases where the retrobulbar spot sign (RBSS) was observed, but central retinal artery occlusion (CRAO) was not confirmed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Transorbital sonography was employed to detect the presence of RBSS in all patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>RBSS was detected in all three patients. However, only one patient had CRAO, with RBSS-positive findings in both eyes, although one eye showed normal function. The other two patients exhibited RBSS without evidence of CRAO. RBSS remained unchanged in all four eyes during the follow-up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RBSS may not be specific to CRAO, as it was observed in non-CRAO cases. Further research is necessary to clarify its diagnostic significance and differentiate it from other pathologies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1764893","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:34:56Z","timestamp":1779251696000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Retrobulbar spot sign in non-ischemic conditions: a case series challenging its diagnostic role"],"prefix":"10.3389","volume":"13","author":[{"given":"Chuanjie","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Shandong Second Medical University Affiliated Qingdao Eighth People's Hospital","place":["Qingdao, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiezhi","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Shandong Second Medical University Affiliated Qingdao Eighth People's Hospital","place":["Qingdao, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiliang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Brain Center, Shandong Second Medical University Affiliated Qingdao Eighth People's Hospital","place":["Qingdao, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaohu","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Brain Center, Shandong Second Medical University Affiliated Qingdao Eighth People's Hospital","place":["Qingdao, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shandong Second Medical University Affiliated Qingdao Eighth People's Hospital","place":["Qingdao, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shandong Second Medical University Affiliated Qingdao Eighth People's Hospital","place":["Qingdao, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huadong","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shandong Second Medical University Affiliated Qingdao Eighth People's Hospital","place":["Qingdao, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"91","DOI":"10.4103\/2221-6189.312217","article-title":"Ocular point-of-care ultrasound: the current evidence","volume":"10","author":"Ho","year":"2021","journal-title":"J Acute Dis"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s42466-025-00413-z","article-title":"Retinal ischemia due to different stages of atherosclerosis - insights from a retrospective study on central retinal artery occlusion","volume":"7","author":"Schlachetzki","year":"2025","journal-title":"Neurol Res Pract"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2322","DOI":"10.1161\/STROKEAHA.115.009839","article-title":"Retrobulbar spot sign predicts thrombolytic treatment effects and etiology in central retinal artery occlusion","volume":"46","author":"Nedelmann","year":"2015","journal-title":"Stroke"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1112312","DOI":"10.3389\/fneur.2023.1112312","article-title":"Implications of quantitative susceptibility mapping at 7 tesla MRI for microbleeds detection in cerebral small vessel disease","volume":"14","author":"Perosa","year":"2023","journal-title":"Front Neurol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1055\/a-0942-7750","article-title":"Optic disc Drusen","volume":"236","author":"Tonagel","year":"2019","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.3390\/jcm8091449","article-title":"Detection of optic disc drusen in children using ultrasound through the lens and avoiding the lens-point of care ultrasound technique of evaluation revisited","volume":"8","author":"Rajagopal","year":"2019","journal-title":"J Clin Med"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1764893\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:35:10Z","timestamp":1779251710000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1764893\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,20]]},"references-count":6,"alternative-id":["10.3389\/fmed.2026.1764893"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1764893","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,20]]},"article-number":"1764893"}}