{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T08:01:59Z","timestamp":1772006519449,"version":"3.50.1"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hypertensive disorders of pregnancy are a major cause of maternal and perinatal morbidity and mortality, particularly among women of advanced maternal age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      This retrospective study evaluated the correlation between echocardiographic parameters and adverse pregnancy outcomes in 240 women aged \u226535\u202fyears diagnosed with pregnancy-induced hypertension syndrome (PIHS) from February 2019 to June 2022. Patients were classified into a favorable outcome group (\n                      <jats:italic>n<\/jats:italic>\n                      =\u202f183) and an adverse outcome group (\n                      <jats:italic>n<\/jats:italic>\n                      =\u202f57). Echocardiographic indicators\u2014including ejection fraction (EF), stroke volume (SV), cardiac output (CO), E\/A ratio, early diastolic mitral annular velocity (E\u2032), E\/E\u2032 ratio, left atrial volume index (LAVI), pulmonary venous flow velocities (S-, D-, Ar-waves), and myocardial performance (Tei) index\u2014were compared between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Women with adverse outcomes had significantly lower EF, SV, CO, E\/A ratio, and E\u2032, while showing higher E\/E\u2032, LAVI, Ar-wave velocity, and Tei index, with reduced S- and D-wave velocities (all\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.001). A history of hypertension, nephritis, and a family history of hypertension were also identified as significant clinical risk factors. Multivariable logistic regression confirmed that both clinical and echocardiographic parameters were independently associated with poor outcomes. Receiver operating characteristic analysis demonstrated high discriminative power for key indices (AUC range: 0.78\u20130.90), and a combined model integrating multiple echocardiographic variables achieved an AUC of 0.925, indicating excellent predictive performance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These findings suggest that multi-parameter echocardiographic assessment provides a reliable, non-invasive approach for identification of high-risk PIHS patients, supporting more effective monitoring and timely intervention to improve maternal and fetal prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1766747","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T07:05:42Z","timestamp":1772003142000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation between multi-parameter echocardiographic indicators and adverse pregnancy outcomes in women of advanced maternal age with pregnancy-induced hypertension syndrome: clinical application value"],"prefix":"10.3389","volume":"13","author":[{"given":"Jing","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Xiangyang No. 1 People's Hospital, Hubei University of Medicine","place":["Xiangyang, Hubei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Xiangyang No. 1 People's Hospital, Hubei University of Medicine","place":["Xiangyang, Hubei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"100864","DOI":"10.1016\/j.jacadv.2024.100864","article-title":"Hypertensive disorders of pregnancy: innovative management strategies","volume":"3","author":"Radparvar","year":"2024","journal-title":"JACC Adv"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1097\/HJH.0000000000003739","article-title":"Management of hypertensive disorders in pregnancy: a position statement of the European Society of Hypertension Working Group \u201chypertension in women\u201d","volume":"42","author":"Thomopoulos","year":"2024","journal-title":"J Hypertens"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"S1222","DOI":"10.1016\/j.ajog.2020.08.018","article-title":"Guidelines\u2014similarities and dissimilarities: a systematic review of international clinical practice 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