{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T06:17:03Z","timestamp":1778221023325,"version":"3.51.4"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to evaluate the predictive value of the Fibrosis-4 (FIB-4) index for 28-day mortality in patients with acute pancreatitis and to develop a comprehensive prognostic model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 467 adult patients admitted to the intensive care unit. Risk factors for 28-day mortality were identified through univariate and subsequent multivariate logistic regression analyses. Based on the significant independent predictors, a predictive logistic regression model was formulated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multivariate analysis revealed that age, APACHE II score, WBC, serum sodium, and the FIB-4 index were independent predictors of 28-day mortality. The combined model incorporating these five factors achieved an area under the receiver operating characteristic curve (AUC) of 0.80, which was significantly higher than that of the FIB-4 index alone (AUC\u202f=\u202f0.69,\n                      <jats:italic>Z<\/jats:italic>\n                      =\u202f3.65,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.01) and the APACHE II alone (AUC\u202f=\u202f0.73,\n                      <jats:italic>Z<\/jats:italic>\n                      =\u202f3.84,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study confirms the independent prognostic value of the FIB-4 index, and its integration into a multivariable model provides a practical tool to improve early mortality risk stratification in acute pancreatitis patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1767483","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T05:54:49Z","timestamp":1778219689000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between the Fibrosis-4 index and mortality risk in acute pancreatitis"],"prefix":"10.3389","volume":"13","author":[{"given":"Lijie","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, West China Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruoran","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Medical Centre, Chinese PLA General Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, West China Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, West China Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1097\/MPA.0b013e31823db941","article-title":"Epidemiology of first-attack acute pancreatitis in Taiwan from 2000 through 2009: a nationwide population-based 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