{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T09:28:54Z","timestamp":1774430934457,"version":"3.50.1"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Autoimmune liver disease is predominantly characterized by autoimmune hepatitis and primary biliary cholangitis. In clinical practice, patients with autoimmune liver disease may progress to cirrhosis and subsequently develop multiple complications of decompensated cirrhosis, such as ascites, hepatic encephalopathy, and gastrointestinal hemorrhage. However, spontaneous hepatic rupture hemorrhage in patients with autoimmune liver disease is exceedingly rare. This article presents a case of presumed spontaneous hepatic rupture hemorrhage in a patient with autoimmune hepatitis-primary biliary cholangitis overlap syndrome and cirrhosis. Through multidisciplinary evaluation, conservative management was selected, achieving successful hemostasis. This report aims to provide a reference for the clinical recognition and management of such rare complications.<\/jats:p>","DOI":"10.3389\/fmed.2026.1767862","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T06:55:26Z","timestamp":1774421726000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Rare spontaneous hepatic rupture hemorrhage complicated by autoimmune liver disease"],"prefix":"10.3389","volume":"13","author":[{"given":"Limin","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Liaocheng People\u2019s Hospital","place":["Liaocheng, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changming","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Liaocheng People\u2019s Hospital","place":["Liaocheng, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jichun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Dongchangfu District Hospital of Traditional Chinese Medicine","place":["Liaocheng, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Liaocheng People\u2019s Hospital","place":["Liaocheng, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Liaocheng People\u2019s Hospital","place":["Liaocheng, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.jhep.2013.09.020","article-title":"Autoimmune 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In the diagnosis of ruptured liver cancer","volume":"20","author":"Li","year":"2014","journal-title":"Contemp Med"},{"key":"ref15","first-page":"159","article-title":"Computed tomography and angiographic interventional features of ruptured hepatocellular carcinoma: pictorial essay","volume":"57","author":"Kim","year":"2006","journal-title":"Can Assoc Radiol J"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"2026846","DOI":"10.1155\/2018\/2026846","article-title":"Hepatic rupture induced by spontaneous intrahepatic hematoma","volume":"2018","author":"Zhou","year":"2018","journal-title":"Case Rep Surg"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1767862\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T06:55:36Z","timestamp":1774421736000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1767862\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,25]]},"references-count":16,"alternative-id":["10.3389\/fmed.2026.1767862"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1767862","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,25]]},"article-number":"1767862"}}