{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T14:24:28Z","timestamp":1773930268010,"version":"3.50.1"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    Malignant gastrointestinal neuroectodermal tumor (M-GNET), also known as clear cell sarcoma-like tumor of the gastrointestinal tract (CCSLTGT) or clear cell sarcoma-like tumor of the gastrointestinal tract with osteoclast-like giant cells, is a rare malignant tumor that typically arises in the gastrointestinal tract. It demonstrates primitive neural or neuroectodermal differentiation but lacks melanocytic features. M-GNET is closely related to clear cell sarcoma of soft tissue (CCSST), sharing highly overlapping morphological features and molecular genetic characteristics, particularly\n                    <jats:italic>EWSR1-ATF1<\/jats:italic>\n                    gene fusion and, more rarely,\n                    <jats:italic>EWSR1-CREB1<\/jats:italic>\n                    gene fusion. Most M-GNETs occur in the lower gastrointestinal tract, while only a few cases have been reported in the upper gastrointestinal tract and outside the digestive tract. We present the primary M-GNET in the pancreas, confirmed by molecular fluorescence\n                    <jats:italic>in situ<\/jats:italic>\n                    hybridization (FISH) detection of\n                    <jats:italic>EWSR1-ATF1<\/jats:italic>\n                    gene fusion. This article will summarize the clinicopathological features and differential diagnosis and review the relevant literature.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2026.1768345","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T11:28:01Z","timestamp":1773919681000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A rare case of clear cell sarcoma-like\/malignant gastrointestinal neuroectodermal tumor in the pancreas: case report and literature review"],"prefix":"10.3389","volume":"13","author":[{"given":"Jing","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pathology, Guangxi Medical University Cancer Hospital","place":["Nanning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathology, Guangxi Medical University Cancer Hospital","place":["Nanning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Guangxi Medical University Cancer Hospital","place":["Nanning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Zhen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Guangxi Medical University Cancer Hospital","place":["Nanning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ru-Wei","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Guangxi Medical University Cancer Hospital","place":["Nanning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Xia","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Pathology, Guangxi Medical University Cancer Hospital","place":["Nanning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Ming","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Guangxi Medical University Cancer Hospital","place":["Nanning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Qi","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Guangxi Medical University Cancer Hospital","place":["Nanning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1002\/1097-0142(196509)18:9<>3.0.co;2-0","article-title":"Clear-cell sarcoma of tendons and aponeuroses. 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