{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T05:06:43Z","timestamp":1775797603714,"version":"3.50.1"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    We report two cases of severe lower limb soft tissue infection caused by\n                    <jats:italic>Aeromonas<\/jats:italic>\n                    following traumatic injury. A 26-year-old male sustained propeller injury with fractures and developed progressive infection complicated by septic shock and necrotizing fasciitis, requiring left femoral mid-shaft amputation. A 58-year-old male suffered an open tibial plateau fracture and presented with wound infection that resolved after antimicrobial treatment but was followed by tetanus. Both patients had positive cultures for\n                    <jats:italic>Aeromonas hydrophila<\/jats:italic>\n                    (and\n                    <jats:italic>Aeromonas caviae<\/jats:italic>\n                    in the second case) identified via matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry (MALDI-TOF MS) combined with biochemical characterization. Antimicrobial susceptibility testing was performed using the broth microdilution method per CLSI 2024 guidelines, guiding targeted antibiotic therapy. Both patients achieved favorable outcomes after comprehensive management including surgical debridement, targeted antimicrobial treatment, and supportive care, with no recurrence during follow-up. This report summarizes the clinical diagnosis, treatment strategies, and prognosis of post-traumatic\n                    <jats:italic>Aeromonas<\/jats:italic>\n                    infection, highlighting the importance of timely microbiological identification, susceptibility testing, and multidisciplinary intervention for improving outcomes in such cases.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2026.1772258","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T04:25:27Z","timestamp":1775795127000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Post-traumatic Aeromonas infection causing severe lower limb soft tissue infection\u2014a report of two surviving cases"],"prefix":"10.3389","volume":"13","author":[{"given":"Cui","family":"Shang","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Daping Hospital, Army Medical University","place":["Chongqing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yushan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Daping Hospital, Army Medical University","place":["Chongqing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shili","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Daping Hospital, Army Medical University","place":["Chongqing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengbin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Daping Hospital, Army Medical University","place":["Chongqing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuxia","family":"Jian","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Daping Hospital, Army Medical University","place":["Chongqing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"113710","DOI":"10.1016\/j.foodres.2023.113710","article-title":"Aeromonas spp. in drinking water and food: occurrence, virulence potential and antimicrobial resistance","volume":"175","author":"Carusi","year":"2024","journal-title":"Food Res Int"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1159\/000501847","article-title":"Aeromonas hydrophila Panophthalmitis in pemphigus vulgaris: a case report","volume":"10","author":"Thanapaisal","year":"2019","journal-title":"Case Rep Ophthalmol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1128\/CMR.00039-09","article-title":"The genus Aeromonas: taxonomy, pathogenicity, and infection","volume":"23","author":"Janda","year":"2010","journal-title":"Clin Microbiol Rev"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1002\/ams2.409","article-title":"Successful support by veno-arterial extracorporeal membrane oxygenation for severe septic shock caused by Aeromonas hydrophila","volume":"6","author":"Ishida","year":"2019","journal-title":"Acute Med Surg"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3855\/jidc.17530","article-title":"Bacteremia caused by Aeromonas species in patients with cancer: clinical manifestations and outcomes","volume":"17","author":"Alatorre-Fern\u00e1ndez","year":"2023","journal-title":"J Infect Dev Ctries"},{"key":"ref6","volume-title":"M100Ed34. Performance Standards for Antimicrobial Susceptibility Testing: 34th Informational Supplement","year":"2024"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3390\/microorganisms8010129","article-title":"An update on the genus Aeromonas: taxonomy, epidemiology, and pathogenicity","volume":"8","author":"Fern\u00e1ndez-Bravo","year":"2020","journal-title":"Microorganisms"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.4269\/ajtmh.18-0393","article-title":"Case report: Bothrops lanceolatus snakebite surgical management-relevance of fasciotomy","volume":"99","author":"Severyns","year":"2018","journal-title":"Am J Trop Med Hyg"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"3374","DOI":"10.1128\/JCM.42.7.3374-3376.2004","article-title":"Bacteriology of a bear bite wound to a human: case report","volume":"42","author":"Kunimoto","year":"2004","journal-title":"J Clin Microbiol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.cmi.2018.11.006","article-title":"A case of leech-associated infection involving an extended-spectrum \u03b2-lactamase-producing and extensively drug-resistant Aeromonas hydrophila","volume":"25","author":"Floug","year":"2019","journal-title":"Clin Microbiol Infect"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1086\/671008","article-title":"Catheter-related bacteremia caused by Aeromonas hydrophila in a hemodialysis patient","volume":"34","author":"Zhou","year":"2013","journal-title":"Infect Control Hosp Epidemiol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s12328-019-01020-7","article-title":"A case of phlegmonous gastritis with hepatic portal venous gas caused by Aeromonas hydrophila successfully treated with medication","volume":"13","author":"Yasuda","year":"2020","journal-title":"Clin J Gastroenterol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"e37","DOI":"10.22037\/aaem.v12i1.2270","article-title":"Fatal septic shock due to Aeromonas hydrophila in a cirrhotic patient; a case report","volume":"12","author":"Hoa","year":"2024","journal-title":"Arch Acad Emerg Med"},{"key":"ref14","first-page":"185","article-title":"Analysis of 16S rRNA gene mutations in a subset of Aeromonas strains and their impact in species delineation","volume":"11","author":"Alperi","year":"2008","journal-title":"Int Microbiol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.3390\/microorganisms9071536","article-title":"Matrix-assisted laser desorption\/ionization time of flight mass spectrometry (MALDI-TOF MS) analysis for the identification of pathogenic microorganisms: a review","volume":"9","author":"Chen","year":"2021","journal-title":"Microorganisms"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s00253-024-13055-z","article-title":"Antimicrobial resistance in aeromonads and new therapies targeting quorum sensing","volume":"108","author":"Neil","year":"2024","journal-title":"Appl Microbiol Biotechnol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1247652","DOI":"10.3389\/fmicb.2023.1247652","article-title":"De novo whole transcriptome analysis of Aeromonas hydrophila isolated from the gut of an infected Labeo rohita","volume":"14","author":"Das","year":"2023","journal-title":"Front Microbiol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.toxicon.2014.12.001","article-title":"Tetanus after envenomations caused by freshwater stingrays","volume":"97","author":"Torrez","year":"2015","journal-title":"Toxicon"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1016\/S0140-6736(18)33131-3","article-title":"Tetanus","volume":"393","author":"Yen","year":"2019","journal-title":"Lancet"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"582","DOI":"10.47102\/annals-acadmedsg.V34N9p582","article-title":"Wound infections in tsunami survivors: a commentary","volume":"34","author":"Lim","year":"2005","journal-title":"Ann Acad Med Singap"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1093\/clinids\/14.3.689","article-title":"Catfish-related injury and infection: report of two cases and review of the literature","volume":"14","author":"Murphey","year":"1992","journal-title":"Clin Infect Dis"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/0882-4010(91)90003-S","article-title":"An extracellular acetylcholinesterase produced by Aeromonas hydrophila is a major lethal toxin for fish","volume":"11","author":"Nieto","year":"1991","journal-title":"Microb Pathog"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.micpath.2019.05.017","article-title":"Aeromonas hydrophila infection in silver catfish causes hyperlocomotion related to stress","volume":"132","author":"Bandeira Junior","year":"2019","journal-title":"Microb Pathog"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1772258\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T04:25:30Z","timestamp":1775795130000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1772258\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,10]]},"references-count":23,"alternative-id":["10.3389\/fmed.2026.1772258"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1772258","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,10]]},"article-number":"1772258"}}