{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T14:03:10Z","timestamp":1775570590199,"version":"3.50.1"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Porto-sinusoidal vascular disease (PSVD) is an increasingly recognized cause of non-cirrhotic portal hypertension, characterized by structural abnormalities of the portal microvasculature and hepatic sinusoids in the absence of cirrhosis. Recognized predisposing factors include immune-mediated conditions, infections and exposure to hepatic sinusoid-toxic agents, among others. We report a 44-year-old woman with a history of oxaliplatin-based chemotherapy for colon cancer who presented with recurrent hematochezia, hematemesis, and transient encephalopathy. Evaluation demonstrated portal hypertension and portal vein thrombosis; however, liver biopsy showed no cirrhosis and the hepatic venous pressure gradient (HVPG) was within normal limits. Her medication history, combined with these findings, confirmed the diagnosis of oxaliplatin-induced PSVD. This case highlights the importance of considering PSVD in patients with non-cirrhotic portal hypertension, particularly when there is a history of exposure to agents toxic to the hepatic sinusoids, such as oxaliplatin.<\/jats:p>","DOI":"10.3389\/fmed.2026.1772653","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T06:43:10Z","timestamp":1771483390000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Oxaliplatin-induced porto-sinusoidal vascular disease manifesting as recurrent gastroesophageal variceal hemorrhage: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Ruiqi","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu","place":["Sichuan, 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