{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T05:09:27Z","timestamp":1775797767588,"version":"3.50.1"},"reference-count":7,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Surgical treatment of idiopathic uveal effusion syndrome (UES) is challenging with high risks. CO\n                      <jats:sub>2<\/jats:sub>\n                      laser-assisted sclerectomy surgery (CLASS) is potentially a semiquantitative, quick and safe surgical option. This study aimed to describe the feasibility and early outcomes of CO\n                      <jats:sub>2<\/jats:sub>\n                      laser-assisted sclerectomy surgery (CLASS) with sclerostomy for idiopathic uveal effusion syndrome (UES).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a prospective descriptive case series. After fully exposed, the sclera was ablated with CO\n                      <jats:sub>2<\/jats:sub>\n                      laser beam repeatedly until a bluish hue was visible. A crescent blade was used to make scleral incision in the same plane with the floor of the scleral pool. The lamellar sclera was cut, and the scleral pool was enlarged. A 1\u202f\u00d7\u202f1\u202fmm\n                      <jats:sup>2<\/jats:sup>\n                      sclerostomy was created in each sclerectomy bed with a 15 degree stab blade.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The technique was used in three eyes of three patients with UES and exudative retinal detachment (RD). After a mean follow-up of 410\u202fdays (range, 34\u2013825\u202fdays), all patients demonstrated sustained improvement of RD, with complete resolution in two cases. No adverse events were observed during the extended follow-up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CLASS with sclerostomy appears to be a feasible and durable technique for UES in this small series, though further studies are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1775395","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T04:27:36Z","timestamp":1775795256000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["CO2 laser-assisted sclerectomy with sclerostomy for uveal effusion syndrome"],"prefix":"10.3389","volume":"13","author":[{"given":"Mingyue","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences","place":["Beijing, China"]},{"name":"Beijing Key Laboratory of Fundus Diseases Intelligent Diagnosis & Drug\/Device Development and Translation","place":["Beijing, China"]},{"name":"Key Lab of Ocular Fundus Diseases, Chinese Academy of Medical Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"Xi\u2019an People\u2019s Hospital (Xi\u2019an Fourth Hospital), Shannxi Eye Hospital","place":["Xi\u2019an, Shannxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences","place":["Beijing, China"]},{"name":"Beijing Key Laboratory of Fundus Diseases Intelligent Diagnosis & Drug\/Device Development and Translation","place":["Beijing, China"]},{"name":"Key Lab of Ocular Fundus Diseases, Chinese Academy of Medical Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youxin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences","place":["Beijing, China"]},{"name":"Beijing Key Laboratory of Fundus Diseases Intelligent Diagnosis & Drug\/Device Development and Translation","place":["Beijing, China"]},{"name":"Key Lab of Ocular Fundus Diseases, Chinese Academy of Medical Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meifen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences","place":["Beijing, China"]},{"name":"Beijing Key Laboratory of Fundus Diseases Intelligent Diagnosis & Drug\/Device Development and Translation","place":["Beijing, China"]},{"name":"Key Lab of Ocular Fundus Diseases, Chinese Academy of Medical Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences","place":["Beijing, China"]},{"name":"Beijing Key Laboratory of Fundus Diseases Intelligent Diagnosis & Drug\/Device Development and Translation","place":["Beijing, China"]},{"name":"Key Lab of Ocular Fundus Diseases, Chinese Academy of Medical Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongping","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences","place":["Beijing, China"]},{"name":"Beijing Key Laboratory of Fundus Diseases Intelligent Diagnosis & Drug\/Device Development and Translation","place":["Beijing, China"]},{"name":"Key Lab of Ocular Fundus Diseases, Chinese Academy of Medical Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s40123-022-00601-z","article-title":"Medical therapy and scleral windows for uveal effusion syndrome: a case series and literature review","volume":"12","author":"Li","year":"2023","journal-title":"Ophthalmol Ther"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"100973","DOI":"10.1016\/j.preteyeres.2021.100973","article-title":"Venous overload choroidopathy: a hypothetical framework for central serous chorioretinopathy and allied disorders","volume":"86","author":"Spaide","year":"2022","journal-title":"Prog Retin Eye Res"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"785444","DOI":"10.3389\/fmed.2022.785444","article-title":"Uveal effusion syndrome: clinical characteristics, outcome of surgical treatment, and histopathological examination of the sclera","volume":"9","author":"Zhou","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e659","DOI":"10.1111\/aos.14383","article-title":"Survival of the best? - why some surgical techniques such as deep sclerectomy 'fail'","volume":"98","author":"van Setten","year":"2020","journal-title":"Acta Ophthalmol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1097\/IJG.0b013e31820e2ccd","article-title":"CO2 laser-assisted sclerectomy surgery part I: concept and experimental models","volume":"21","author":"Ton","year":"2012","journal-title":"J Glaucoma"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1097\/ijg.0000000000000437","article-title":"Mid-term clinical results of CO2 laser-assisted sclerectomy surgery (CLASS) for open-angle glaucoma treatment","volume":"25","author":"Geffen","year":"2016","journal-title":"J Glaucoma"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"270","DOI":"10.3892\/etm.2023.11969","article-title":"An overview and update of CO(2) laser-assisted sclerectomy surgery in primary open angle glaucoma (review)","volume":"25","author":"Huang","year":"2023","journal-title":"Exp Ther Med"}],"container-title":["Frontiers in 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