{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T05:13:39Z","timestamp":1776230019620,"version":"3.50.1"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007322","name":"Binzhou Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>17q12 deletion syndrome is a rare autosomal dominant disorder classically characterized by renal cystic disease, maturity-onset diabetes of the young type 5 (MODY5), and M\u00fcllerian duct anomalies (e. g., MRKH syndrome).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>Pancreatic manifestations in this syndrome commonly include congenital structural abnormalities (e.g., dorsal agenesis) or atrophy, whereas classic chronic pancreatitis is rarely documented. We report an 18-year-old female with recurrent upper abdominal pain, steatorrhea, and dyspepsia. Imaging revealed pancreatic atrophy with calcifications. Whole-exome sequencing confirmed a diagnosis of 17q12 deletion syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case is the first to identify chronic pancreatitis as a significant clinical phenotype of 17q12 deletion syndrome. By integrating a literature review, we discuss the pathophysiology related to hepatocyte nuclear factor 1\u03b2 (HNF1B) haploinsufficiency, suggesting that chronic pancreatitis may constitute part of the syndrome's clinical spectrum.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1775502","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T04:39:50Z","timestamp":1776227990000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["17q12 deletion syndrome presenting with chronic pancreatitis: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Meng-zhen","family":"Liu","sequence":"first","affiliation":[{"name":"Binzhou Medical University Hospital","place":["Binzhou, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-fei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Binzhou Medical University Hospital","place":["Binzhou, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Shao","sequence":"additional","affiliation":[{"name":"Shandong University of Aeronautics","place":["Binzhou, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-di","family":"Guan","sequence":"additional","affiliation":[{"name":"Binzhou Medical University Hospital","place":["Binzhou, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-chen","family":"Dong","sequence":"additional","affiliation":[{"name":"Binzhou Medical University Hospital","place":["Binzhou, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Binzhou Medical University Hospital","place":["Binzhou, Shandong, 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