{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:44:42Z","timestamp":1793295882554,"version":"4.5.0"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Obstructive sleep apnea (OSA) is a condition defined by complex biological causes and highly varied symptoms. The traditional \u201cone-size-fits-all\u201d treatment approach, which depends on a single measurement like the Apnea-Hypopnea Index (AHI), frequently fails to provide individualized care, leading to poor results and low treatment adherence for many patients. Precision medicine offers a solution by using many different types of data to create detailed patient profiles. This data includes the specific physical causes of a patient\u2019s OSA, their unique symptoms and other health conditions, biological markers, and information from ongoing monitoring. This detailed profiling allows doctors to group patients more precisely and match them to targeted treatments, such as procedures to open the airway, medications to stabilize breathing, and personalized lifestyle changes. The goal is to shift OSA care from a focus on standardized devices to plans built around the individual patient. To make this future a reality, the medical field needs standardized tools for patient profiling, strong clinical trials to prove these new methods work, and better teamwork across medical specialties. This coordinated effort is essential to make care for OSA more effective, personalized, and accessible to all who need it.<\/jats:p>","DOI":"10.3389\/fmed.2026.1776553","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T16:33:19Z","timestamp":1776097999000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["A perspective on precision medicine in obstructive sleep apnea: from pathophysiological phenotyping to integrated management pathways"],"prefix":"10.3389","volume":"13","author":[{"given":"Yan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Yan'an University","place":["Yan\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Si","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Yan'an University","place":["Yan\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Ni","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Yan'an Vocational and Technical College","place":["Yan\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Yan'an University","place":["Yan\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/s41569-023-00846-6","article-title":"Obstructive sleep apnoea heterogeneity and cardiovascular disease","volume":"20","author":"Redline","year":"2023","journal-title":"Nat Rev Cardiol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1001\/jama.2023.17465","article-title":"Adherence to CPAP treatment and the risk of recurrent cardiovascular events: a Meta-analysis","volume":"330","author":"S\u00e1nchez-de-la-Torre","year":"2023","journal-title":"JAMA"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"7586","DOI":"10.3390\/jcm14217586","article-title":"Advancing obstructive sleep apnea management: recent trends from conventional to innovative therapies","volume":"14","author":"Park","year":"2025","journal-title":"J Clin Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"943","DOI":"10.3390\/healthcare10050943","article-title":"Obstructive sleep apnea and adherence to continuous positive airway pressure (CPAP) treatment: let's talk about partners!","volume":"10","author":"Rosa","year":"2022","journal-title":"Healthcare (Basel)"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1080\/17476348.2022.2112669","article-title":"Obstructive sleep apnea: personalizing CPAP alternative therapies to individual physiology","volume":"16","author":"Nokes","year":"2022","journal-title":"Expert Rev Respir Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1016\/j.fertnstert.2018.05.006","article-title":"Personalized medicine: motivation, challenges, and progress","volume":"109","author":"Goetz","year":"2018","journal-title":"Fertil Steril"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1164\/rccm.201901-0014TR","article-title":"More than the sum of the respiratory events: personalized medicine approaches for obstructive sleep apnea","volume":"200","author":"Edwards","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.smrv.2016.10.002","article-title":"Phenotypes in obstructive sleep apnea: a definition, examples and evolution of approaches","volume":"35","author":"Zinchuk","year":"2017","journal-title":"Sleep Med Rev"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"567","DOI":"10.34197\/ats-scholar.2023-0022OT","article-title":"Obstructive sleep apnea: pathophysiology and Endotypes","volume":"4","author":"Sanchez-Azofra","year":"2023","journal-title":"ATS Sch"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1097\/MCP.0000000000000724","article-title":"Endotypes and phenotypes in obstructive sleep apnea","volume":"26","author":"Malhotra","year":"2020","journal-title":"Curr Opin Pulm Med"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"e000218","DOI":"10.1136\/bmjmed-2022-000218","article-title":"Role of precision medicine in obstructive sleep apnoea","volume":"2","author":"Liu","year":"2023","journal-title":"BMJ Med"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.smrv.2016.12.003","article-title":"Phenotypic approaches to obstructive sleep apnoea - 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