{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T06:33:22Z","timestamp":1772778802292,"version":"3.50.1"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intestinal tuberculosis (ITB) complicated by sinus tract is clinically characterized by nonspecific symptoms. This condition necessitates multidisciplinary collaboration, and a multidimensional differential diagnostic approach integrating clinical manifestations, imaging findings, and pathological examination is imperative for confirmation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>A 26-year-old female presented with a 1-month history of recurrent right lower abdominal pain. She had previously been misdiagnosed with appendicitis and Crohn\u2019s disease (CD). Through a comprehensive diagnostic workup including small intestine computed tomography enterography (CTE), purified protein derivative (PPD) test, colonoscopy, and pathological assessment, the patient was diagnosed with ITB complicated by a sinus tract of the ascending colon. Quadruple anti-tuberculosis therapy was initiated. Notably, the fistula achieved complete closure 6\u202fmonths post-treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights the critical importance of multidisciplinary diagnosis and treatment in managing ITB. It provides valuable reference material for the clinical diagnosis of such rare complications, thereby contributing to improved clinical decision-making in similar cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1777309","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T05:30:07Z","timestamp":1772775007000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Intestinal tuberculosis mimicking Crohn\u2019s disease with ascending colon sinus tract: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Yiting","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, First Affiliated Hospital of Shantou University Medical College","place":["Shantou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, First Affiliated Hospital of Shantou University Medical College","place":["Shantou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1186\/s12889-023-15553-7","article-title":"Geographical evolutionary pathway of global tuberculosis incidence trends","volume":"23","author":"Lei","year":"2023","journal-title":"BMC Public Health"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.ijid.2022.12.005","article-title":"Extrapulmonary tuberculosis in China: a national survey","volume":"128","author":"Li","year":"2023","journal-title":"Int J Infect Dis"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1405358","DOI":"10.3389\/fpubh.2024.1405358","article-title":"Analysis of epidemiological characteristics of extrapulmonary tuberculosis from south-Central China","volume":"12","author":"Yu","year":"2024","journal-title":"Front Public Health"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"261","DOI":"10.4103\/sjg.sjg_148_21","article-title":"Gastrointestinal tuberculosis: a systematic review of epidemiology, presentation, diagnosis and treatment","volume":"27","author":"Al-Zanbagi","year":"2021","journal-title":"Saudi J Gastroenterol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s12876-022-02171-7","article-title":"Recent advances in the diagnosis of intestinal tuberculosis","volume":"22","author":"Maulahela","year":"2022","journal-title":"BMC Gastroenterol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"820134","DOI":"10.3389\/fimmu.2022.820134","article-title":"In the thick of it: formation of the tuberculous granuloma and its effects on host and therapeutic responses","volume":"13","author":"Cronan","year":"2022","journal-title":"Front Immunol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1093\/infdis\/jiv076","article-title":"The extracellular matrix regulates granuloma necrosis in tuberculosis","volume":"212","author":"Al Shammari","year":"2015","journal-title":"J Infect Dis"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/s12879-023-08550-z","article-title":"Case report: a case report and literature analysis on intestinal tuberculosis intestinal perforation complicated by umbilical intestinal fistula and bladder ileal fistula","volume":"23","author":"Liu","year":"2023","journal-title":"BMC Infect Dis"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"275","DOI":"10.4103\/1658-631X.213301","article-title":"Spontaneous tubercular enterocutaneous fistula","volume":"5","author":"Shah","year":"2017","journal-title":"Saudi J Med Med Sci"},{"key":"ref10","first-page":"416","article-title":"A case of intestinal tuberculosis associated with ileo-ileal fistula","volume":"107","author":"Miura","year":"2010","journal-title":"Nihon Shokakibyo Gakkai zasshi"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.ijid.2021.12.342","article-title":"Challenging diagnosis of abdominal tuberculosis in children: case report","volume":"116","author":"Lukosiute-Urboniene","year":"2022","journal-title":"Int J Infect Dis"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1186\/s12876-023-02887-0","article-title":"Differentiating gastrointestinal tuberculosis and Crohn's disease- a comprehensive review","volume":"23","author":"Choudhury","year":"2023","journal-title":"BMC Gastroenterol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1616608","DOI":"10.3389\/fped.2025.1616608","article-title":"Clinical characteristics leading to misdiagnosis of abdominal tuberculosis in children: a systematic review and meta-analysis","volume":"13","author":"Siddiqui","year":"2025","journal-title":"Front Pediatr"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"6306","DOI":"10.3748\/wjg.v23.i34.6306","article-title":"Temporal trends in the misdiagnosis rates between Crohn's disease and intestinal tuberculosis","volume":"23","author":"Seo","year":"2017","journal-title":"World J Gastroenterol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1093\/ecco-jcc\/jjv164","article-title":"Clinical features of tuberculous versus Crohn's anal fistulas, in Korea","volume":"9","author":"Choi","year":"2015","journal-title":"J Crohns Colitis"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1007\/s00384-015-2208-8","article-title":"Combined identifying granuloma and biopsy culture is useful for diagnosing intestinal tuberculosis","volume":"30","author":"Sekine","year":"2015","journal-title":"Int J Color Dis"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"6053503","DOI":"10.1155\/2019\/6053503","article-title":"Intestinal tuberculosis masquerading as Crohn's disease? A case of disseminated tuberculosis after anti-TNF therapy for suspected Crohn's disease","volume":"2019","author":"Abadir","year":"2019","journal-title":"Case Rep Gastrointest Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"4167","DOI":"10.1128\/AAC.00874-09","article-title":"Prospective randomized trial of six-month versus nine-month therapy for intestinal tuberculosis","volume":"53","author":"Park","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"547","DOI":"10.2174\/1568026621999201211200447","article-title":"Tuberculosis: an update on pathophysiology, molecular mechanisms of drug resistance, newer anti-TB drugs, treatment regimens and host- directed therapies","volume":"21","author":"Borah","year":"2021","journal-title":"Curr Top Med Chem"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1777309\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T05:30:08Z","timestamp":1772775008000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1777309\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,6]]},"references-count":19,"alternative-id":["10.3389\/fmed.2026.1777309"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1777309","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,6]]},"article-number":"1777309"}}