{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T12:03:28Z","timestamp":1777637008106,"version":"3.51.4"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>This article reports a case of a patient with Cronkhite-Canada syndrome combined with sigmoid colon cancer and early esophageal cancer. In this case, CCS was diagnosed simultaneously with the discovery of sigmoid colon cancer and early esophageal cancer. After radical resection of sigmoid colon cancer, the patient received hormone therapy for 12 months. The symptoms such as diarrhea, hair loss, and malnutrition were relieved, and the gastric-duodenal and colonic polyp-like lesions were reduced. The early esophageal cancer was followed up for 3 years, but no active treatment was given for the early esophageal cancer. It is rare for both colon cancer and early esophageal cancer to occur simultaneously on the basis of CCS. To improve the understanding of the diagnosis and treatment of this disease and postoperative management, the case is reported as follows.<\/jats:p>","DOI":"10.3389\/fmed.2026.1778538","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:59:59Z","timestamp":1777442399000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: A case of Cronkhite-Canada syndrome associated with sigmoid colon cancer and early esophageal cancer"],"prefix":"10.3389","volume":"13","author":[{"given":"Yumeng","family":"Wang","sequence":"first","affiliation":[{"name":"Graduate School, Hebei North University","place":["Zhangjiakou, China"]},{"name":"Department of Geriatric Gastroenterology, Hebei General Hospital","place":["Shijiazhuang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Geriatric Gastroenterology, Hebei General Hospital","place":["Shijiazhuang, China"]},{"name":"Graduate School, North China University of Science and Technology","place":["Tangshan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Geriatric Gastroenterology, Hebei General Hospital","place":["Shijiazhuang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conghui","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Geriatric Gastroenterology, Hebei General Hospital","place":["Shijiazhuang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qicheng","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Geriatric Gastroenterology, Hebei General Hospital","place":["Shijiazhuang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Geriatric Gastroenterology, Hebei General Hospital","place":["Shijiazhuang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Geriatric Gastroenterology, Hebei General Hospital","place":["Shijiazhuang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1056\/NEJM195506162522401","article-title":"Generalized gastrointestinal polyposis; 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