{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:23:29Z","timestamp":1791509009507,"version":"4.3.4"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic obstructive pulmonary disease (COPD) is a widespread chronic illness that affects millions of people around the world. Its management not only necessitates medical intervention but also long-term patient self-management. Most traditional self-management education fails to address individualized needs and ongoing support. With improvements in information technology, especially in the application of artificial intelligence (AI) for health management, new avenues have emerged that can improve COPD patients\u2019 self-management capacity, ultimately leading to better disease control and improved quality of life. Thus, we have developed an AI Health Education Accurately Linking System (AI-HEALS) to examine if AI-HEALS-based intervention is effective in enhancing COPD patients\u2019 ability for self-management, ultimately leading to better disease management and improved quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This randomized controlled trial (RCT) aims to evaluate the efficacy of AI-HEALS intervention implemented through WeChat platform in improving self-management ability of COPD patients. Eligible COPD patients meeting the inclusion criteria will be randomly assigned to either an intervention group or a control group. The control group will receive standard treatment, while the intervention group will receive the AI-HEALS program in addition to standard treatment. The AI-HEALS system is an AI driven question and answer platform with integrated voice interaction capabilities, designed to facilitate easier interaction between patients and the system. It provides real-time physiological monitoring, medication and behavior reminders, and personalized health education through the \u201cCOPD Health Management Expert\u201d WeChat platform. The system is supported by a self-developed knowledge base based on established clinical guidelines and evidence for COPD, ensuring the accuracy and reliability of the information provided. Outcome measurements will be conducted at multiple time points, including baseline (upon enrollment), hospital discharge, the end of the intervention, and at 3, 6, and 9 months after the completion of the intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Ethical approval for the study was obtained from the Medical Ethics Committee of Zigong First People\u2019s Hospital [Ethics No. Ethics (Research) 2024, Issue 152, 31\/10\/2024]. The clinical trial is registered under ChiCTR2400092829, with registration completed on 25\/11\/2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Protocol Registration<\/jats:title>\n                    <jats:p>\n                      [\n                      <jats:ext-link>https:\/\/www.chictr.org.cn\/bin\/home<\/jats:ext-link>\n                      ], identifier [ChiCTR2400092829].\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1782018","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T16:03:24Z","timestamp":1774368204000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Study protocol: Artificial Intelligence Health Education Accurately Linking System for enhancing self-management in chronic obstructive pulmonary disease patients via WeChat"],"prefix":"10.3389","volume":"13","author":[{"given":"Ju","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Zigong First People\u2019s Hospital","place":["Zigong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Hua","family":"Li","sequence":"additional","affiliation":[{"name":"School of Education, Chengdu College of Arts and Sciences","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"He","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Zigong First People\u2019s Hospital","place":["Zigong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Zigong First People\u2019s Hospital","place":["Zigong, 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