{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:57:27Z","timestamp":1782284247327,"version":"3.54.5"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women of reproductive age. This study aimed to determine self-reported prevalence of physician-diagnosed PCOS among young medical students at King Saud University and to compare it with reported rates from Western and international populations of similar age. In addition, it assessed the awareness among female medical students at King Saud University.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional study was conducted using a structured self-administered questionnaire distributed to female medical students at King Saud University between December 2024 and March 2025. The survey contained sociodemographic data, PCOS-related signs and symptoms, past medical history, lifestyle factors, knowledge about PCOS and its complications. Statistical analyses included bivariate analysis and multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We collected 303 responses. The self-reported prevalence of physician-diagnosed PCOS was 18.5%. Common symptoms included hair loss (60.7%), acne (49.8%), and weight gain (32%). PCOS diagnosis was significantly associated with age group (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.015), BMI (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.038), menstrual irregularities (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), hirsutism (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), weight gain (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.004), diabetes mellitus (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), and family history (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001). Multivariable logistic regression identified hirsutism (OR\u202f=\u202f4.36,\n                      <jats:italic>p<\/jats:italic>\n                      =\u202f0.005) to be significantly associated with self-reported physician-diagnosed PCOS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The observed prevalence in young medical students in this study was higher than that reported in several Western populations of similar age. Recognition of contributing factors such as genetic susceptibility and lifestyle patterns is essential. Greater emphasis on early screening and targeted health education is recommended.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1782062","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T05:23:40Z","timestamp":1776662620000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["High prevalence of poly cystic ovary syndrome among young Saudi medical students: an observational cross-sectional study"],"prefix":"10.3389","volume":"13","author":[{"given":"Thamer","family":"Alsufayan","sequence":"first","affiliation":[{"name":"Department of Physiology, College of Medicine, King Saud University","place":["Riyadh, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musaad","family":"Alsahly","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine, King Saud University","place":["Riyadh, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoor K.","family":"Aloraini","sequence":"additional","affiliation":[{"name":"College of Medicine, King Saud University","place":["Riyadh, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thamir","family":"Al-khlaiwi","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine, King Saud University","place":["Riyadh, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"ref1","first-page":"356","article-title":"PCOS: symptoms and awareness in urban Pakistani women","volume":"2","author":"Gul","year":"2014","journal-title":"Int J Pharma Res Health Sci"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"395","DOI":"10.29121\/granthaalayah.v6.i9.2018.1252","article-title":"Polycystic ovarian syndrome(pcos), awareness among female students, Qassim 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Psychosom Res"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.fertnstert.2016.05.003","article-title":"Criteria, prevalence, and phenotypes of polycystic ovary syndrome","volume":"106","author":"Lizneva","year":"2016","journal-title":"Fertil Steril"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1093\/aje\/kwn137","article-title":"A simple screening approach for assessing community prevalence and phenotype of polycystic ovary syndrome in a semi urban population in Sri Lanka","volume":"168","author":"Kumarapeli","year":"2008","journal-title":"Am J Epidemiol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.jpag.2011.03.002","article-title":"Prevalence of polycystic ovarian syndrome in Indian adolescents","volume":"24","author":"Nidhi","year":"2011","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1210\/jc.2003-032046","article-title":"The prevalence and features of the polycystic ovary syndrome in an unselected population","volume":"89","author":"Azziz","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"ref10","first-page":"3078","article-title":"Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study","volume":"83","author":"Knochenhauer","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"ref11","first-page":"186","article-title":"Prevalence of polycystic ovary syndrome, and relationship with obesity\/overweight: cross-sectional study in Saudi Arabia","volume":"10","author":"Aldossary","year":"2020","journal-title":"J Adv Pharm Educ Res"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1514250","DOI":"10.3389\/fpubh.2025.1514250","article-title":"Global burden of polycystic ovary syndrome among women of childbearing age, 1990-2021: a systematic analysis using the global burden of disease study 2021","volume":"13","author":"Meng","year":"2025","journal-title":"Front Public Health"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"96351","DOI":"10.18632\/oncotarget.19180","article-title":"The prevalence of polycystic ovary syndrome in reproductive-aged women of different ethnicity: a systematic review and meta-analysis","volume":"8","author":"Ding","year":"2017","journal-title":"Oncotarget"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"53","DOI":"10.5430\/jnep.v8n8p53","article-title":"Knowledge, attitude and practice related to reproductive health among female adolescents","volume":"8","author":"Gaferi","year":"2018","journal-title":"J Nurs Educ Pract"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"13","DOI":"10.9734\/jpri\/2023\/v35i27311","article-title":"Prevalence and risk factors of polycystic ovarian syndrome PCOS: cross-sectional study","volume":"35","author":"Mohmed","year":"2023","journal-title":"J Pharm Res Int"},{"key":"ref16","first-page":"2290","article-title":"Prevalence and knowledge of polycystic ovary syndrome (PCOS) among female medical students, King Khalid University","volume":"46","author":"Alqasem","year":"2024","journal-title":"Bahrain Med Bull"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1089\/whr.2023.0176","article-title":"Prevalence of and risk factors associated with polycystic ovary syndrome among female university students of health sciences in a middle eastern country","volume":"5","author":"Alkhezi","year":"2024","journal-title":"Womens Health Rep (New Rochelle)"},{"key":"ref18","first-page":"1","article-title":"Prevalence of polycystic ovarian syndrome and its relation to urinary tract symptoms among female medical students of umm Al-Qura University","volume":"8","author":"Ghazzawi","year":"2024","journal-title":"J Obstet Gynecol 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Gynecol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"333","DOI":"10.4103\/ijmr.IJMR_1937_17","article-title":"Epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in India","volume":"150","author":"Ganie","year":"2019","journal-title":"Indian J Med Res"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1652954","DOI":"10.3389\/fmed.2025.1652954","article-title":"Ovarian lipid metabolic alterations in polycystic ovary syndrome: insights from proton magnetic resonance spectroscopy","volume":"12","author":"Wang","year":"2025","journal-title":"Front Med (Lausanne)"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.18203\/2320-1770.ijrcog20250847","article-title":"Prevalence and risk factors of polycystic ovary syndrome among reproductive-aged women","volume":"14","author":"Khatun","year":"2025","journal-title":"Int J Reprod Contracept Obstet Gynecol"},{"key":"ref25","first-page":"117","article-title":"A study on 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