{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T04:56:24Z","timestamp":1788411384852,"version":"build-2803163510"},"reference-count":93,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>An increasing number of studies have explored the effects of exercise on pain, fatigue, and quality of life (QOL) in fibromyalgia patients, yet the available results remain inconsistent. This study aimed to examine the effects of exercise on pain, fatigue, and QOL in fibromyalgia patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature search, restricted to studies published up to 30 July 2025, was conducted across five databases: Embase, PubMed, Cochrane Library, Web of Science, and Scopus. The search utilized the following keywords: exercise, fibromyalgia, pain, fatigue, and quality of life. A meta-analysis was performed to calculate the standardized mean difference (SMD) and 95% confidence interval.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty-four studies were included in this meta-analysis. Exercise had a positive effect on alleviating pain (SMD, \u22120.77;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.00001), fatigue (SMD, \u22120.39;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.03), and QOL (SMD, 0.53;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.00001) in fibromyalgia patients. Subgroup analyses showed that aerobic exercise (SMD, \u22120.83;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.0002) conducted for \u22658\u202fweeks (SMD, \u22120.73;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.006), &amp;lt;3 times per week (SMD, \u22121.12;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.0009), 60\u201390\u202fmin per session (SMD, \u22121.35;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.0001), and &amp;lt;180\u202fmin per week (SMD, \u22120.96;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.001) were more effective in alleviating pain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Exercise significantly improved pain, fatigue, and QOL in fibromyalgia patients. To alleviate pain, fibromyalgia patients are recommended to engage in aerobic exercise for at least 8\u202fweeks, 60\u201390\u202fmin per session, twice weekly, without exceeding 180\u202fmin weekly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/www.crd.york.ac.uk\/PROSPERO\/view\/CRD42023493753<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1782714","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T05:33:27Z","timestamp":1771392807000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of exercise on pain, fatigue, and quality of life in people with fibromyalgia: a systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.3389","volume":"13","author":[{"given":"Tongling","family":"Wang","sequence":"first","affiliation":[{"name":"School of Sports Science, Nantong University","place":["Nantong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Su","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Sports Performance and Skill Assessment, Beijing Sport University","place":["Beijing, China"]},{"name":"Department of Strength and Conditioning Assessment and Monitoring, Beijing Sport University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Strength and Conditioning Assessment and Monitoring, Beijing Sport University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwen","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Strength and Conditioning Assessment and Monitoring, Beijing Sport University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Lv","sequence":"additional","affiliation":[{"name":"China Institute of Sport and Health Science, Beijing Sport University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laikang","family":"Yu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Sports Performance and Skill Assessment, Beijing Sport University","place":["Beijing, China"]},{"name":"Department of Strength and Conditioning Assessment and Monitoring, Beijing Sport University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.3390\/jcm9041219","article-title":"Diagnostic criteria for fibromyalgia: critical review and future perspectives","volume":"9","author":"Galvez-S\u00e1nchez","year":"2020","journal-title":"J Clin Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.rdc.2022.02.006","article-title":"Fibromyalgia: recognition and management in the primary care office","volume":"48","author":"Gota","year":"2022","journal-title":"Rheum Dis Clin N Am"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"117","DOI":"10.2147\/prbm.S178240","article-title":"Psychological impact of fibromyalgia: current perspectives","volume":"12","author":"Galvez-S\u00e1nchez","year":"2019","journal-title":"Psychol Res Behav 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