{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T09:22:50Z","timestamp":1774430570475,"version":"3.50.1"},"reference-count":135,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010211","name":"Education Department of Jilin Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    Doxorubicin (DOX)-induced cardiotoxicity significantly impairs patients' quality of life and long-term prognosis, and can lead to irreversible cardiac dysfunction and heart failure years or even decades after chemotherapy has ceased. Natural medicinal products represent a promising strategy for preventing or treating this cardiotoxicity, with\n                    <jats:italic>Salvia miltiorrhiza<\/jats:italic>\n                    (Danshen) demonstrating therapeutic properties in this context. Considerable attention has been focused on Tanshinone IIA, the principal lipophilic diterpenoid quinone compound found in Danshen, for its potential efficacy against doxorubicin-induced cardiac injury. Its therapeutic mechanisms include alleviating oxidative stress, inhibiting cardiomyocyte apoptosis, exerting anti-inflammatory effects in the myocardium, attenuating cardiac fibrosis, and modulating cardiomyocyte autophagy. This article provides an in-depth elaboration of the mechanisms and targets through which Tan IIA counteracts doxorubicin-induced cardiotoxicity. Furthermore, we explored Tan IIA drug delivery systems (DDS) and device-assisted delivery platforms, thus offering novel insights for future research and clinical translation of Tan IIA, as well as presenting new strategies for addressing doxorubicin-induced cardiac injury.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2026.1783433","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T06:51:30Z","timestamp":1774421490000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The multifaceted mechanisms of Tanshinone IIA in doxorubicin-induced cardiotoxicity"],"prefix":"10.3389","volume":"13","author":[{"given":"Qinqin","family":"Wang","sequence":"first","affiliation":[{"name":"College of Traditional Chinese Medicine, Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danqi","family":"Zou","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Cui","sequence":"additional","affiliation":[{"name":"College of Basic Medicine, Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xupeng","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqiu","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Basic Medicine, Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Qi","sequence":"additional","affiliation":[{"name":"College of Basic Medicine, Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Nan","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Changchun University of Chinese Medicine","place":["Changchun, Jilin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Basic Medicine, Changchun University of Chinese Medicine","place":["Changchun, 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