{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T06:11:45Z","timestamp":1777961505306,"version":"3.51.4"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Patients with severe aplastic anemia (SAA) complicated by mucormycosis face a significantly elevated risk of mortality and present considerable therapeutic challenges. This study aimed to delineate nursing management and propose a structured care model for a case of SAA complicated by mucormycosis undergoing allogeneic hematopoietic stem cell transplantation (HSCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The case involved an 18-years-old female with SAA and a progressive right oromaxillofacial mucormycosis ulcer. During salvage allogeneic HSCT, a nurse-led multidisciplinary team implemented care informed by a structured model. Core interventions were structured around four pillars: (1) a multi-tiered infection control strategy; (2) an innovative wound management protocol combining systemic antifungals with local amphotericin B wet dressings; (3) predictive management of complications; and (4) staged and individualized psychological support. The entire nursing process was guided by the Omaha System as the theoretical framework for problem assessment and intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The patient successfully achieved hematopoietic engraftment. The mucormycosis infection was effectively controlled without further dissemination, and the facial wound decreased significantly in size. A critical Grade 3 cytokine release syndrome was successfully managed. The patient maintained a favorable prognosis at the 1-year follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates that a structured and nurse-led model of care is pivotal for successfully managing highly complex HSCT patients with life-threatening co-infections. The Omaha System provided a robust and effective framework for delivering systematic and holistic care in this challenging clinical scenario.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1784004","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T05:31:45Z","timestamp":1777959105000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Salvage allogeneic hematopoietic stem cell transplantation in a patient with preexisting refractory maxillofacial mucormycosis and severe aplastic anemia: a case report and nursing care model"],"prefix":"10.3389","volume":"13","author":[{"given":"Wenjuan","family":"Cao","sequence":"first","affiliation":[{"name":"Laminar Air-Flow Research Unit, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuhui","family":"Wu","sequence":"additional","affiliation":[{"name":"Laminar Air-Flow Research Unit, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/bjh.13853","article-title":"Guidelines for the diagnosis and management of adult aplastic anaemia.","volume":"172","author":"Killick","year":"2016","journal-title":"British J Haematol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1038\/bmt.2015.117","article-title":"Recommendations on hematopoietic stem cell transplantation for inherited bone marrow failure syndromes.","volume":"50","author":"Peffault de Latour","year":"2015","journal-title":"Bone Marrow 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cytokine release syndrome and neurologic toxicity associated with immune effector cells.","volume":"25","author":"Lee","year":"2018","journal-title":"Biol Blood Marrow Transplant."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1016\/j.bbmt.2016.06.010","article-title":"Severe cytokine-release syndrome after T cell-replete peripheral blood haploidentical donor transplantation is associated with poor survival and anti-IL-6 therapy is safe and well tolerated.","volume":"22","author":"Abboud","year":"2016","journal-title":"Biol Blood Marrow Transplant."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2265","DOI":"10.1200\/jco-25-00713","article-title":"BMT-CARE app: a randomized controlled trial of a psychosocial digital application for caregivers of patients undergoing hematopoietic stem-cell transplantation.","volume":"43","author":"Jacobs","year":"2025","journal-title":"J Clin Oncol."}],"container-title":["Frontiers in 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