{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T06:16:19Z","timestamp":1778220979294,"version":"3.51.4"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate changes in anterior segment parameters before and after laser peripheral iridotomy (LPI) in patients with primary angle closure suspect (PACS), analyze the role of anterior chamber anatomical changes in the development of primary angle closure glaucoma (PACG), and assess the clinical value of LPI in PACS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      A total of 42 patients (42 eyes) diagnosed with PACS and treated with LPI at the Ophthalmology Department of Shaoxing People\u2019s Hospital between January 2023 and April 2025 were included. Anterior chamber volume (ACV), anterior chamber depth (ACD), and anterior chamber angle (ACA) were measured using the Sirius anterior segment analysis system before surgery and at 1\u202fweek and 3\u202fmonths postoperatively. Visual acuity, intraocular pressure, and corneal endothelial cell density were also assessed. Comparisons among time points were performed using SPSS 25.0, with\n                      <jats:italic>p<\/jats:italic>\n                      \u202f\u2264\u202f0.05 considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      This study included 7 males and 35 females aged 41\u201384\u202fyears (mean age, 62.62\u202f\u00b1\u202f9.50\u202fyears), with a mean axial length of 22.09\u202f\u00b1\u202f0.82\u202fmm. There were no significant differences in visual acuity or intraocular pressure across the three time points (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;gt;\u202f0.05). Corneal endothelial cell density showed no significant change between preoperative and 1-week postoperative measurements (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;gt;\u202f0.05). In contrast, ACD increased significantly from 1.87\u202f\u00b1\u202f0.04\u202fmm preoperatively to 2.02\u202f\u00b1\u202f0.05\u202fmm at 1\u202fweek and 2.03\u202f\u00b1\u202f0.05\u202fmm at 3\u202fmonths postoperatively (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). ACV increased significantly from 113.48\u202f\u00b1\u202f3.18\u202fmm3 preoperatively to 123.06\u202f\u00b1\u202f2.54\u202fmm3 at 1\u202fweek and 122.50\u202f\u00b1\u202f2.18\u202fmm3 at 3\u202fmonths (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05), and ACA widened significantly from 30.26\u202f\u00b1\u202f0.65\u00b0 to 33.90\u202f\u00b1\u202f0.79\u00b0 and 33.34\u202f\u00b1\u202f0.79\u00b0, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LPI in patients with PACS is safe, as it does not adversely affect visual acuity, intraocular pressure, or corneal endothelial cell density. The procedure significantly deepens the anterior chamber, increases ACV, and widens the ACA, supporting its role in improving anterior segment anatomy and potentially delaying progression to primary angle closure and PACG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1784392","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T05:56:25Z","timestamp":1778219785000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes in anterior segment parameters after laser peripheral iridotomy in patients with primary angle closure suspect"],"prefix":"10.3389","volume":"13","author":[{"given":"Qi","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Shaoxing People's Hospital, Zhejiang University","place":["Shaoxing, China"]},{"name":"School of Medicine, Shaoxing University","place":["Shaoxing, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zenghui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shaoxing People's Hospital, Zhejiang University","place":["Shaoxing, China"]},{"name":"School of Medicine, Shaoxing University","place":["Shaoxing, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daliang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shaoxing People's Hospital, Zhejiang University","place":["Shaoxing, China"]},{"name":"School of Medicine, Shaoxing University","place":["Shaoxing, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guomei","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shaoxing People's Hospital, Zhejiang University","place":["Shaoxing, China"]},{"name":"School of Medicine, Shaoxing University","place":["Shaoxing, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shaoxing People's Hospital, Zhejiang University","place":["Shaoxing, China"]},{"name":"School of Medicine, Shaoxing University","place":["Shaoxing, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shaoxing People's Hospital, Zhejiang University","place":["Shaoxing, China"]},{"name":"School of Medicine, Shaoxing University","place":["Shaoxing, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shaoxing People's Hospital, Zhejiang University","place":["Shaoxing, China"]},{"name":"School of Medicine, Shaoxing University","place":["Shaoxing, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shaoxing People's Hospital, Zhejiang University","place":["Shaoxing, China"]},{"name":"School of Medicine, Shaoxing University","place":["Shaoxing, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surong","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shaoxing People's Hospital, Zhejiang University","place":["Shaoxing, China"]},{"name":"School of Medicine, Shaoxing University","place":["Shaoxing, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a 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suspect","volume":"43","author":"\u015eahin","year":"2023","journal-title":"Int Ophthalmol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3969\/j.issn.1673-3835.2017.04.010","article-title":"The application of Pentacam anterior segment analysis system in the evaluation of laser peripheral iris resection surgery","volume":"12","author":"Hongjie","year":"2017","journal-title":"Pract Anti-Blindness Technol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1016\/j.ophtha.2018.01.015","article-title":"Laser peripheral iridotomy in primary angle closure: a report by the American Academy of ophthalmology","volume":"125","author":"Radhakrishnan","year":"2018","journal-title":"Ophthalmology"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"CD015116","DOI":"10.1002\/14651858.CD015116.pub2","article-title":"Lens extraction versus laser peripheral iridotomy for acute primary angle 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