{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:30:51Z","timestamp":1793197851027,"version":"4.5.0"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      (\n                      <jats:italic>H. pylori<\/jats:italic>\n                      ) infects approximately half of the world\u2019s population and is more prevalent in developing countries. It is a major risk factor for gastric cancer, which ranks fifth worldwide in both incidence and mortality. French Guiana is a French overseas territory located in the Amazon region and presents several characteristics that may favor\n                      <jats:italic>H. pylori<\/jats:italic>\n                      transmission compared with mainland France, including immigration from neighboring low-income countries, widespread socioeconomic vulnerability, a limited number of specialized healthcare professionals. In addition, the incidence of gastric cancer is high in this territory. However, the prevalence of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection in this territory remains unknown. The aim of this study was to determine the histological prevalence of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection in gastric biopsies, describe the clinical and histological characteristics of infected patients, and assess follow-up outcomes after diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>\n                      A retrospective study was conducted at Cayenne Hospital from January to December 2023 among patients with histologically confirmed\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      was detected in 570 of 1,664 patients (34.3%). Among these, 545 infected patients were included in the analysis, of whom 57% were women. The mean age was 49.5\u202fyears. Two-thirds of the patients were foreign-born. The main indications for upper gastrointestinal endoscopy were epigastric pain (53%), gastroesophageal reflux disease (20%), and abdominal pain (19%). Histological examination revealed gastric adenocarcinoma in 1.65% of cases and gastric precancerous lesions in 28.4%, including 6.6% severe lesions requiring endoscopic surveillance. Regarding follow-up, only 52% (95% CI 47.8\u201356.3) of patients were aware of their diagnosis and 48% (95% CI 44.7\u201353.2) received eradication therapy, while 19% (95% CI 15.8\u201322.6) were lost to follow-up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The histological prevalence of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection was 34.3%. Despite the presence of gastric precancerous lesions in nearly one-third of patients, post-diagnosis follow-up remained inadequate.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1785533","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:40:00Z","timestamp":1777351200000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Histological prevalence of Helicobacter pylori in patients undergoing upper gastrointestinal endoscopy at Cayenne Hospital and follow-up outcomes"],"prefix":"10.3389","volume":"13","author":[{"given":"Amandine","family":"Allard","sequence":"first","affiliation":[{"name":"Service d\u2019H\u00e9pato-Gastroent\u00e9rologie, CHU de Guyane","place":["Cayenne, French Guiana"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marthe","family":"Alogo A 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Guiana"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corine","family":"Fozeu","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9pato-Gastroent\u00e9rologie, CHU de Guyane","place":["Cayenne, French Guiana"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedia","family":"Mahjoub","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9pato-Gastroent\u00e9rologie, CHU de Guyane","place":["Cayenne, French Guiana"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Atodjinou","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9pato-Gastroent\u00e9rologie, CHU de Guyane","place":["Cayenne, French Guiana"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Zerouali","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9pato-Gastroent\u00e9rologie, CHU de Guyane","place":["Cayenne, French 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