{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:25:23Z","timestamp":1777890323379,"version":"3.51.4"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"\n Background<\/jats:title>\n Peutz\u2013Jeghers syndrome (PJS) is an autosomal dominant disorder characterized by mucocutaneous pigmentation, gastrointestinal hamartomatous polyps, and an increased risk of specific neoplasms, including distinctive gynecological tumors.<\/jats:p>\n <\/jats:sec>\n \n Case presentation<\/jats:title>\n This study reports a rare case of a 25-year-old woman with a confirmed diagnosis of PJS who presented with watery vaginal discharge. Gynecological evaluation revealed concurrent cervical and ovarian masses. Histopathology of the cervical lesion demonstrated lobular endocervical glandular hyperplasia (LEGH), while the ovarian mass was identified as a sex-cord tumor with annular tubules (SCTATs), exhibiting both simple and complex ring-like tubules surrounding hyaline cores.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This case represents an uncommon co-occurrence of LEGH and SCTATs in a single PJS patient, highlighting the broad spectrum of PJS-associated gynecologic pathology. This study underscores the need for early and regular gynecological surveillance in women with PJS.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fmed.2026.1785608","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:35:29Z","timestamp":1777613729000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Peutz\u2013Jeghers syndrome with concurrent lobular endocervical glandular hyperplasia and sex cord tumor with annular tubules: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Min","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Gynecology, Qilu Hospital of Shandong University, (Qingdao), Cheeloo College of Medicine, Shandong University","place":["Qingdao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunli","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, Qilu Hospital of Shandong University (Qingdao), Cheeloo College of Medicine, Shandong University","place":["Qingdao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Qilu Hospital of Shandong University, (Qingdao), Cheeloo College of Medicine, Shandong University","place":["Qingdao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"5530710","DOI":"10.1155\/humu\/5530710","article-title":"Genetic investigation and transcriptome profiling in a nuclear family with Peutz-Jeghers syndrome","volume":"2025","author":"Khan","year":"2025","journal-title":"Hum Mutat"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.ygyno.2025.04.001","article-title":"STK11 adnexal tumor: a newly recognized entity that expands the spectrum of neoplasms associated with Peutz-Jeghers syndrome","volume":"197","author":"Bennett","year":"2025","journal-title":"Gynecol Oncol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.pathol.2025.08.001","article-title":"Cytology and histology of endocervical glandular lesions: a review with emphasis on recent developments","volume":"57","author":"Banet","year":"2025","journal-title":"Pathology"},{"key":"ref4","volume-title":"Peutz-Jeghers Syndrome","author":"Sherman","year":"2025"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1159\/000529799","article-title":"Clinical guidelines for diagnosis and Management of Peutz-Jeghers Syndrome in children and adults","volume":"104","author":"Yamamoto","year":"2023","journal-title":"Digestion"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/ajg.2014.435","article-title":"ACG clinical guideline: genetic testing and management of hereditary 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cases","volume":"61","author":"Lee","year":"2018","journal-title":"Obstetr Gynecol Scie"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.3892\/ol.2013.1527","article-title":"Hereditary gynecological tumors associated with Peutz-Jeghers syndrome (review)","volume":"6","author":"Banno","year":"2013","journal-title":"Oncol Lett"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1007\/s00595-015-1296-y","article-title":"Update on our investigation of malignant tumors associated with Peutz-Jeghers syndrome in Japan","volume":"46","author":"Ishida","year":"2016","journal-title":"Surg Today"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"101941","DOI":"10.1016\/j.gore.2025.101941","article-title":"Peutz-Jeghers syndrome in gynecological cancers: bibliometric trends, clinical insights, and future directions","volume":"61","author":"Niu","year":"2025","journal-title":"Gynecol Oncol Rep"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"3056","DOI":"10.1111\/jog.15441","article-title":"Biology and management of lobular endocervical glandular hyperplasia","volume":"48","author":"Miyamoto","year":"2022","journal-title":"J Obstet Gynaecol Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"332","DOI":"10.2463\/mrms.rev.2024-0198","article-title":"Lobular endocervical glandular hyperplasia and related glandular disorders: current status of diagnosis with MR imaging","volume":"24","author":"Ohya","year":"2025","journal-title":"Magn Reson Med Sci"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.jogc.2020.06.025","article-title":"Sex cord tumour with annular tubules-an unusual case of abdominal pain","volume":"43","author":"Senn","year":"2021","journal-title":"J Obstetr Gynaeco Can"}],"container-title":["Frontiers in 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