{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:46:24Z","timestamp":1782279984406,"version":"3.54.5"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    <jats:italic>Streptococcus sinensis<\/jats:italic>\n                    (\n                    <jats:italic>S. sinensis<\/jats:italic>\n                    ) is a rare pathogen causing infective endocarditis (IE). We report a 68\n                    <jats:bold>-<\/jats:bold>\n                    year\n                    <jats:bold>-<\/jats:bold>\n                    old Chinese man with\n                    <jats:italic>S. sinensis-<\/jats:italic>\n                    associated IE complicated by cerebral infarction with hemorrhagic transformation. He presented with fever, aphasia, arthralgia, arthritis, and right hemiparesis. Initial transthoracic echocardiography was negative for vegetations; valve-adjacent vegetations were identified until after neurological stabilization. Antimicrobial therapy was adjusted iteratively according to culture and susceptibility results. Linezolid plus cefazolin for 4\u202fweeks achieved his condition stabilization; the patient declined valve replacement and was discharged. Oral linezolid plus moxifloxacin was continued for another 4\u202fweeks, with sustained stability.\n                    <jats:italic>S. sinensis<\/jats:italic>\n                    IE can involve the central nervous system. Early pathogen identification and targeted antimicrobial therapy are crucial for better outcomes.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2026.1786870","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:47:57Z","timestamp":1782276477000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Infective endocarditis complicated with multiple cerebral embolism and hemorrhage caused by Streptococcus sinensis: a rare case report and literature review"],"prefix":"10.3389","volume":"13","author":[{"given":"Hong","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Pharmacy, The First People\u2019s Hospital of Shuangliu District, West China (Airport) Hospital of Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuilin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First People\u2019s Hospital of Shuangliu District, West China (Airport) Hospital of Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The First People\u2019s Hospital of Shuangliu District, West China (Airport) Hospital of Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiwen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The First People\u2019s Hospital of Shuangliu District, West China (Airport) Hospital of Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longbiao","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First People\u2019s Hospital of Shuangliu District, West China (Airport) Hospital of Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Medicine, The First People\u2019s Hospital of Shuangliu District, West China (Airport) Hospital of Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianli","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The First People\u2019s Hospital of Shuangliu District, West China (Airport) Hospital of Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danjie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First People\u2019s Hospital of Shuangliu District, West China (Airport) Hospital of Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/S0140-6736(24)01098-5","article-title":"Infective endocarditis","volume":"404","author":"Li","year":"2024","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1093\/ehjqcco\/qcac012","article-title":"Socioeconomic variations determine the clinical presentation, aetiology, and outcome of infective endocarditis: a prospective cohort study from the ESC-EORP EURO-ENDO (European infective endocarditis) registry","volume":"9","author":"Sengupta","year":"2022","journal-title":"Eur Heart J Qual Care Clin Outcomes"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1128\/JCM.40.3.805-810.2002","article-title":"Streptococcus sinensis sp. nov., a novel species isolated from a patient with infective 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mimicker","volume":"19","author":"San Francisco","year":"2019","journal-title":"Clin Med (Lond)"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"935725","DOI":"10.3389\/fcvm.2022.935725","article-title":"Case report: infective endocarditis caused by Streptococcus sinensis: the first case in mainland China and literature review","volume":"9","author":"Zhang","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"715","DOI":"10.13602\/j.cnki.jcls.2023.09.15","article-title":"A case of infective endocarditis caused by Streptococcus Chinese","volume":"41","author":"Peng","year":"2023","journal-title":"Chin J Clin Lab Sci"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.2147\/IDR.S470483","article-title":"Infective endocarditis caused by Streptococcus Sinensis in a patient with bioprosthetic aortic valve: a case report and literature 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