{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:45:02Z","timestamp":1788965102537,"version":"build-2803163510"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Inverse psoriasis is a special type of psoriasis whose pathogenesis is not yet fully understood, and for which there is no consensus guideline due to marked therapeutic challenges associated with the specific anatomic location of lesions. Immune-mediated inflammation plays a key role in its development, and the lesions are susceptible to friction and humidity, which makes the affected area less tolerant to treatment. In this article, we report a successful case of Inverse psoriasis treated with Guselkumab in a 48-years-old male, who was treated with three subcutaneous injections of Guselkumab and exhibited marked improvement in cutaneous lesions and pruritus at 12 weeks of treatment. A review of the relevant literature was also conducted with the aim of providing clinicians with more references for the treatment of this disease.<\/jats:p>","DOI":"10.3389\/fmed.2026.1789385","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T05:33:43Z","timestamp":1774935223000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Guselkumab is effective in the treatment of Inverse psoriasis: a case report and literature review"],"prefix":"10.3389","volume":"13","author":[{"given":"Zhuochen","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Dermatology, The First Hospital of Hebei Medical University, Shijiazhuang","place":["Hebei, China"]},{"name":"Subcenter of National Clinical Research Center for Skin and Immune Diseases, Shijiazhuang","place":["Hebei, China"]},{"name":"Hebei Technical Innovation Center of Dermatology and Medical Cosmetology Technology, Shijiazhuang","place":["Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The First Hospital of Hebei Medical University, Shijiazhuang","place":["Hebei, China"]},{"name":"Subcenter of National Clinical Research Center for Skin and Immune Diseases, Shijiazhuang","place":["Hebei, China"]},{"name":"Hebei Technical Innovation Center of Dermatology and Medical Cosmetology Technology, Shijiazhuang","place":["Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyu","family":"Tang","sequence":"additional","affiliation":[{"name":"The Second Hospital of Hebei Medical University, Shijiazhuang","place":["Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Hebei Engineering University, Handan","place":["Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The First Hospital of Hebei Medical University, Shijiazhuang","place":["Hebei, China"]},{"name":"Subcenter of National Clinical Research Center for Skin and Immune Diseases, Shijiazhuang","place":["Hebei, China"]},{"name":"Hebei Technical Innovation Center of Dermatology and Medical Cosmetology Technology, Shijiazhuang","place":["Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The First Hospital of Hebei Medical University, Shijiazhuang","place":["Hebei, China"]},{"name":"Subcenter of National Clinical Research Center for Skin and Immune Diseases, Shijiazhuang","place":["Hebei, China"]},{"name":"Hebei Technical Innovation Center of Dermatology and Medical Cosmetology Technology, 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