{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T08:19:33Z","timestamp":1772180373038,"version":"3.50.1"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Intravascular large B-cell lymphoma (IVLBCL) is a rare and aggressive malignancy defined by the proliferation of neoplastic B-cells within the vascular lumen. While the disease can affect multiple organs, commonly manifesting as skin lesions, neurological deficits, or hepatosplenomegaly, it usually spares the lymph nodes and rarely presents as diffuse interstitial lung disease (DILD). We report a 62-year-old man admitted with recurrent fever and progressive dyspnea. Chest computed tomography revealed extensive bilateral interstitial lung disease, with ultrasonography showing generalized lymphadenopathy with preserved architecture. Although initial therapy led to a favorable response, the patient subsequently relapsed. Lymph node biopsy confirmed IVLBCL, characterized by intravascular and intrasinusoidal lymphoma cell infiltration with well-preserved nodal architecture. Notably, the tumor cells showed diffuse strong CD30 expression (~70%), a rare finding potentially linked to the unusual clinical presentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case demonstrates that IVLBCL can present with diffuse interstitial lung disease and generalized lymphadenopathy, expanding its recognized phenotypic spectrum. It may represent a variant with CD30-mediated nodal homing and immune activation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1790176","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:51:42Z","timestamp":1772175102000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A CD30-positive variant of intravascular large B-cell lymphoma presenting as diffuse interstitial lung disease and generalized lymphadenopathy: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Lei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Rizhao Hospital of Traditional Chinese Medicine","place":["Rizhao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongdeng","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Rizhao Hospital of Traditional Chinese Medicine","place":["Rizhao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Rizhao Hospital of Traditional Chinese Medicine","place":["Rizhao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cui","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Rizhao Hospital of Traditional Chinese Medicine","place":["Rizhao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianni","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Rizhao Hospital of Traditional Chinese Medicine","place":["Rizhao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangwei","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Rizhao Hospital of Traditional Chinese Medicine","place":["Rizhao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Respiratory, Linyi Central Hospital","place":["Linyi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changsheng","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Rizhao Hospital of Traditional Chinese Medicine","place":["Rizhao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Rizhao Hospital of Traditional Chinese Medicine","place":["Rizhao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongfang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Rizhao Hospital of Traditional Chinese Medicine","place":["Rizhao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongtao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Rizhao Hospital of Traditional Chinese Medicine","place":["Rizhao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunqing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Affiliated Hospital of Qingdao University","place":["Qingdao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cailing","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Rizhao Hospital of Traditional Chinese Medicine","place":["Rizhao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changjiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Rizhao Hospital of Traditional Chinese Medicine","place":["Rizhao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajing","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Rizhao Hospital of Traditional Chinese Medicine","place":["Rizhao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Rizhao Hospital of Traditional Chinese Medicine","place":["Rizhao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baomei","family":"Mi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Rizhao Hospital of Traditional Chinese Medicine","place":["Rizhao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1093\/qjmed\/hcac169","article-title":"Intravascular large B-cell lymphoma with hot lung sign diagnosed by transbronchial lung cryobiopsy","volume":"115","author":"Michimata","year":"2022","journal-title":"QJM"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"928065","DOI":"10.1155\/2014\/928065","article-title":"Intravascular large B-cell lymphoma presenting as interstitial lung disease","volume":"2014","author":"Khojeini","year":"2014","journal-title":"Case Rep Pathol"},{"key":"ref3","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon: International Agency for Research on Cancer","author":"Swerdlow","year":"2017"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"3821392","DOI":"10.1155\/2018\/3821392","article-title":"Pulmonary Intravascular B-Cell Lymphoma with Angiotropism\/Angioinvasion Mimicking Interstitial Lung Disease: A Clinical Dilemma and Potential Diagnostic Challenge","volume":"2018","author":"Matea","year":"2018","journal-title":"Case Rep Hematol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1182\/blood-2013-09-524108","article-title":"An enhanced International Prognostic Index (NCCN-IPI) for patients with diffuse large B-cell lymphoma treated in the rituximab era","volume":"123","author":"Zhou","year":"2014","journal-title":"Blood"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1182\/blood-2017-04-737445","article-title":"Intravascular large B-cell lymphoma: a chameleon with multiple faces and many masks","volume":"132","author":"Ponzoni","year":"2018","journal-title":"Blood"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1097\/JTO.0000000000000663","article-title":"Introduction to The 2015 World Health Organization Classification of Tumors of the Lung, Pleura, Thymus, and Heart","volume":"10","author":"Travis","year":"2015","journal-title":"J Thorac Oncol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"3168","DOI":"10.1200\/JCO.2006.08.2313","article-title":"Definition, diagnosis, and management of intravascular large B-cell lymphoma: proposals and perspectives from an international consensus meeting","volume":"25","author":"Ponzoni","year":"2007","journal-title":"J Clin Oncol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"E242","DOI":"10.3978\/j.issn.2072-1439.2014.08.45","article-title":"Primary intravascular large B-cell lymphoma of the lung: a review and case report","volume":"6","author":"Chen","year":"2014","journal-title":"J Thorac Dis"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ehpc.2016.11.002","article-title":"Intravascular large B-cell lymphoma mimicking central nervous system vasculitis","volume":"8","author":"Fischer","year":"2017","journal-title":"Human Pathol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"100989","DOI":"10.1016\/j.rmcr.2019.100989","article-title":"Primary lung intravascular large B-Cell lymphoma clinically mimicking sarcoidosis: A rare case report and review of literature","volume":"29","author":"Masood","year":"2020","journal-title":"Respir Med Case Rep"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/1746-1596-7-70","article-title":"Primary intravascular large B-cell lymphoma of lung: a report of one case and review","volume":"7","author":"Yu","year":"2012","journal-title":"Diagn Pathol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"415","DOI":"10.3390\/cancers13030415","article-title":"Primary Pulmonary B-Cell Lymphoma: A Review and Update","volume":"13","author":"Sanguedolce","year":"2021","journal-title":"Cancers (Basel)"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"4571","DOI":"10.21037\/tcr-21-769","article-title":"Intravascular large B-cell lymphoma with diffuse ground glass lesion on chest computed tomography diagnosed using transbronchial lung cryobiopsy: a case report","volume":"10","author":"Zhu","year":"2021","journal-title":"Transl Cancer Res"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.radcr.2018.10.035","article-title":"Intravascular large B-cell lymphoma presenting with diffusely increased pulmonary fluorodeoxyglucose uptake without corresponding CT abnormality","volume":"14","author":"Spencer","year":"2019","journal-title":"Radiol Case Rep"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.5858\/arpa.2021-0165-RA","article-title":"Intravascular large B-cell lymphoma","volume":"146","author":"Davis","year":"2022","journal-title":"Arch Pathol Lab Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1182\/blood-2006-01-021253","article-title":"Intravascular large B-cell lymphoma (IVLBCL): a clinicopathologic study of 96 cases with special reference to the immunophenotypic heterogeneity of CD5","volume":"109","author":"Murase","year":"2007","journal-title":"Blood"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1589052","DOI":"10.3389\/fimmu.2025.1589052","article-title":"Granulomatous lymphocytic interstitial lung disease in common variable immune deficiency: an in-depth clinical, immunological, functional and radiological exploration with a focus on its management, challenged by chronic CMV infection","volume":"16","author":"Moratti","year":"2025","journal-title":"Front Immunol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/j.jaip.2017.01.021","article-title":"British lung foundation\/United Kingdom primary immunodeficiency network consensus statement on the definition, diagnosis, and management of granulomatous-lymphocytic interstitial lung disease in common variable immunodeficiency disorders","volume":"5","author":"Hurst","year":"2017","journal-title":"J Allergy Clin Immunol Pract"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1111\/pin.12871","article-title":"Anaplastic variant of diffuse large B-cell lymphoma: Reappraisal as a nodal disease with sinusoidal involvement","volume":"69","author":"Megahed","year":"2019","journal-title":"Pathol Int"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1016\/j.prp.2017.02.018","article-title":"An Epstein-Barr virus-positive classical Hodgkin lymphoma with exclusive sinusoidal growth pattern: An unusual morphologic variant","volume":"213","author":"Su","year":"2017","journal-title":"Pathol Res Pract"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s00428-025-04189-0","article-title":"Atypical lymphoproliferations associated with germline genetic variants: a report of the 2024 EA4HP\/SH lymphoma workshop","volume":"487","author":"Van den Brand","year":"2025","journal-title":"Virchows Arch"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"e20250174","DOI":"10.70962\/jhi.20250174","article-title":"Lymphoproliferation in inborn errors of immunity: from challenging diagnosis to histologic revision","volume":"2","author":"Moratti","year":"2026","journal-title":"J Hum Immun"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"105650","DOI":"10.1016\/j.humpath.2024.105650","article-title":"Genomic analysis reveals molecular characterization of CD30+ and CD30- extranodal natural killer\/T-cell lymphomas (ENKTLs)","volume":"152","author":"Zhang","year":"2024","journal-title":"Hum Pathol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1111\/cup.13446","article-title":"CD30 expression in a case of intravascular large B-cell lymphoma, cutaneous variant","volume":"46","author":"Provasi","year":"2019","journal-title":"J Cutan Pathol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1182\/blood.v85.1.1.bloodjournal8511","article-title":"CD30 (Ki-1) molecule: a new cytokine receptor of the tumor necrosis factor receptor superfamily as a tool for diagnosis and immunotherapy","volume":"85","author":"Falini","year":"1995","journal-title":"Blood"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1208610","DOI":"10.3389\/fimmu.2023.1208610","article-title":"Clonal composition and differentiation stage of human CD30+ B cells in reactive lymph nodes","volume":"14","author":"K\u00fcppers","year":"2023","journal-title":"Front Immunol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"2996","DOI":"10.1172\/JCI95993","article-title":"Human CD30+ B cells represent a unique subset related to Hodgkin lymphoma cells","volume":"128","author":"Weniger","year":"2018","journal-title":"J Clin Invest"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"2597","DOI":"10.1182\/blood.2018880138","article-title":"Chronic CD30 signaling in B cells results in lymphomagenesis by driving the expansion of plasmablasts and B1 cells","volume":"133","author":"Sperling","year":"2019","journal-title":"Blood"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1038\/s41423-024-01219-w","article-title":"CD30 influences germinal center B-cell dynamics and the expansion of IgG1-switched B cells","volume":"21","author":"Wang","year":"2024","journal-title":"Cell Mol Immunol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"e70072","DOI":"10.1111\/crj.70072","article-title":"Immunological Features and Potential Biomarkers of Systemic Sclerosis-Associated Interstitial Lung Disease and Idiopathic Pulmonary Fibrosis","volume":"19","author":"Shao","year":"2025","journal-title":"Clin Respir J"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.2169\/internalmedicine.56.7613","article-title":"Pulmonary Intravascular Large B-cell Lymphoma (IVLBCL) Disguised as an Asthma Exacerbation in a Patient with Asthma","volume":"56","author":"Takeshige","year":"2017","journal-title":"Intern Med"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1790176\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:51:45Z","timestamp":1772175105000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1790176\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,27]]},"references-count":32,"alternative-id":["10.3389\/fmed.2026.1790176"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1790176","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,27]]},"article-number":"1790176"}}