{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T04:54:09Z","timestamp":1776315249466,"version":"3.50.1"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study evaluates the effectiveness of combining ozone hydrotherapy with scalp complex acid in treating scalp seborrheic dermatitis (SSD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 96 patients with moderate to severe SSD were randomly assigned to either the Control group (treated with scalp complex acid) or the Observation group (treated with a combination of ozone hydrotherapy and scalp complex acid). The treatment period lasted 4 weeks. SSD severity was evaluated using a 16-point composite score that assessed erythema, scaling, and pruritus. Total skin damage score was rated on a 4-point scale. Scalp sebum levels were measured using a Sebumeter SM 810, and serum levels of IL-1\u03b2 and TNF-\u03b1 were quantified using enzyme-linked immunosorbent assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 4 weeks, the Observation group showed significantly greater improvement in erythema, scaling, pruritus, sebum production, and lesion area compared to the Control group. The complete lesion clearance rate was significantly higher in the Observation group (35.6%) than in the Control group (11.6%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.009). Additionally, the Observation group experienced more substantial reductions in skin damage score (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001), Adhesive Scales Flaking Score (ASFS;\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001), and scalp sebum content (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001). Serum levels of IL-1\u03b2 and TNF-\u03b1 were also significantly lower in the Observation group, with IL-1\u03b2 reduced to 59.20 \u00b1 16.19 pg\/mL (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.006) and TNF-\u03b1 reduced to 68.33 \u00b1 18.95 pg\/mL (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The combination of ozone hydrotherapy and scalp complex acid showed enhanced therapeutic benefits for SSD, leading to improved clinical outcomes and a reduction in systemic inflammation.<\/jats:p>\n                  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