{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T06:45:53Z","timestamp":1776235553905,"version":"3.50.1"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the optimal ventilation strategy for pediatric patients with retinoblastoma undergoing selective ophthalmic arterial chemotherapy (SOAC) by comparing the intraoperative effects of volume-controlled (VCV), pressure-controlled (PCV), and pressure-controlled volume-guaranteed (PCV-VG) ventilation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      105 children (aged 1.5\u20135\u202fyears) undergoing SOAC were assigned to three groups: VCV (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f33), PCV (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f37), and PCV-VG (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f35). Hemodynamics, airway pressures, end-expiratory carbon dioxide (EtCO\n                      <jats:sub>2<\/jats:sub>\n                      ), arterial blood gases, and clinical complications were recorded and analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Postoperatively, the peak airway pressure in Group V was significantly higher than those in Group P and Group G. The EtCO\n                      <jats:sub>2<\/jats:sub>\n                      of Group P was closer to normal values than that of the other two groups during surgery\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05. Blood gas results at the three-time points showed that pH and HCO\n                      <jats:sub>3<\/jats:sub>\n                      <jats:sup>\u2212<\/jats:sup>\n                      values of Group P were closer to normal than those of the other two groups immediately after the operation and 5\u202fminutes after the end of angiography, respectively\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05. No significant differences of other indicators were found among the three groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Altogether, compared with the VCV, both PCV and PCV-VG modes produced beneficial lower peak airway pressures during SOAC, thus conducing to prevent mechanical ventilation lung injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1791936","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T05:44:34Z","timestamp":1776231874000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Respiratory ventilation modes in selective ophthalmic arterial chemotherapy for pediatric retinoblastoma under general anesthesia"],"prefix":"10.3389","volume":"13","author":[{"given":"Yuxing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiling","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiegang","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2412","DOI":"10.1056\/nejmicm2118356","article-title":"Retinoblastoma","volume":"386","author":"Peeler","year":"2022","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2356","DOI":"10.4103\/ijo.IJO_721_20","article-title":"Modern treatment of retinoblastoma: a 2020 review","volume":"68","author":"Ancona-Lezama","year":"2020","journal-title":"Indian J Ophthalmol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"822330","DOI":"10.3389\/fonc.2022.822330","article-title":"Treatment of retinoblastoma: what is the latest and what is the future","volume":"12","author":"Schaiquevich","year":"2022","journal-title":"Front 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