{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T17:06:59Z","timestamp":1773335219833,"version":"3.50.1"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Muscle-invasive bladder cancer (MIBC) is associated with poor prognosis. Current staging relies on CT and MRI, but both show limited sensitivity for nodal and distant metastases. [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET\/CT has emerged as a promising tool for staging and response assessment, yet its role remains undefined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>\n                      MIBC-PET is a prospective, monocentric, no-profit study with paired imaging comparison enrolling 60 patients with newly diagnosed, histologically confirmed high-grade MIBC. All patients undergo baseline staging with [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET\/CT and contrast-enhanced CT (ceCT) of chest, abdomen, and pelvis. A second [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET\/CT and CT are performed after two cycles of neoadjuvant therapy. [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET\/CT includes both standard delayed imaging and an early dynamic pelvic acquisition to overcome urinary tracer interference. The primary endpoints are (1) diagnostic accuracy of [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET\/CT vs. ceCT for baseline staging, and (2) accuracy of [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET\/CT in predicting pathological response to neoadjuvant chemotherapy. Secondary endpoints include validation of early dynamic [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET\/CT for local staging and radiomic\/AI-based predictive modeling.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>\n                      The study complies with the Declaration of Helsinki and Good Clinical Practice guidelines. The study was approved by the local ethical committee (CE-AVEC 109-2024-Oss-AOUFe \u2013 P.I. Dr. Luca Urso, MD). Results will inform the integration of [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET\/CT into diagnostic algorithms for MIBC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>ClinicalTrials.gov<\/jats:ext-link>\n                      , identifier: not yet assigned. Local trial registration code: CE-AVEC 109-2024-Oss-AOUFe.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1792243","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:29:28Z","timestamp":1773293368000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic accuracy of 18F-FDG PET\/CT in muscle-invasive bladder cancer: rationale and design of the MIBC-PET study"],"prefix":"10.3389","volume":"13","author":[{"given":"Luca","family":"Urso","sequence":"first","affiliation":[{"name":"Department of Translational Medicine, University of Ferrara","place":["Ferrara, Italy"]},{"name":"Nuclear Medicine Unit, Onco-Hematology Department, University Hospital of Ferrara","place":["Ferrara, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Feletti","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Ferrara","place":["Ferrara, Italy"]},{"name":"Unit\u00e0 Operativa Radiologia, Ospedale S. 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