{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T16:09:46Z","timestamp":1785946186149,"version":"3.56.0"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Positron Emission Tomography (PET) has evolved from a purely diagnostic modality into a cornerstone of precision radiation oncology. PET now informs patient selection, target delineation, treatment personalization, and post-therapy evaluation across External Beam Radiation Therapy (EBRT) and Radiopharmaceutical Therapy (RPT). Radiotracers provide quantitative data on tumor biology, heterogeneity, receptor expression, and therapeutic response, enabling a shift from morphology-based to biology-driven oncology. PET-guided therapy is increasingly used to select patients for molecular radiotherapy, guide EBRT boost volumes, monitor receptor occupancy, and personalize activity prescription. Combined modality approaches\u2014such as EBRT plus PSMA-RLT in prostate cancer or EBRT plus SSTR-RLT in neuroendocrine tumors\u2014are supported by biological rationales involving synergy between external and internal radiation sources. Adaptive strategies based on mid-treatment PET show promise in improving local control while minimizing toxicity. This review summarizes the current landscape and emerging applications of PET-guided therapy, highlighting methodological synergies between EBRT and RPT, strategies for treatment sequencing, biological dose painting, and adaptive therapy. It provides practical recommendations for implementing PET-guided workflows and discusses advances in radiobiology-informed dosimetry, whole-body PET technologies, and novel imaging biomarkers, including fibroblast activation protein inhibitors (FAPI), as key drivers of innovation. As PET technology evolves toward ultra-low-dose, ultra-fast total-body systems, the role of molecular imaging in therapeutic decision-making is expected to expand, ushering in a new era of biologically guided radiation oncology.<\/jats:p>","DOI":"10.3389\/fmed.2026.1794722","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:09:58Z","timestamp":1776262198000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["PET-guided therapy: synergies, strategies, and future directions in external beam radiation therapy and radiopharmaceutical therapy"],"prefix":"10.3389","volume":"13","author":[{"given":"May","family":"Abdel-Wahab","sequence":"first","affiliation":[{"name":"Division of Human Health, Department of Nuclear Sciences and Applications, International Atomic Energy Agency","place":["Vienna, Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Giammarile","sequence":"additional","affiliation":[{"name":"Division of Human Health, Department of Nuclear Sciences and Applications, International Atomic Energy Agency","place":["Vienna, Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.clon.2021.09.004","article-title":"Combining external beam radiation and radionuclide therapies: rationale, radiobiology, results and roadblocks","volume":"33","author":"Abbott","year":"2021","journal-title":"Clin Oncol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"S19","DOI":"10.1259\/bjr\/21263014","article-title":"Positron emission tomography imaging approaches for external beam radiation therapies: current status and future developments","volume":"84","author":"Price","year":"2011","journal-title":"Br J Radiol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1600821","DOI":"10.3389\/fonc.2025.1600821","article-title":"A proof-of-concept study of personalized dosimetry for targeted radioligand therapy using pre-treatment diagnostic dynamic PET\/CT and Monte Carlo simulation","volume":"15","author":"Duong","year":"2025","journal-title":"Front Oncol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.semradonc.2025.05.004","article-title":"PSMA-PET guided radiotherapy in prostate cancer: a critical review of current applications and future directions","volume":"35","author":"Dragonetti","year":"2025","journal-title":"Semin Radiat Oncol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3390\/tomography11080083","article-title":"Emerging PET imaging agents and targeted radioligand therapy: a review of clinical applications and trials","author":"Palihati","year":"2025","journal-title":"Tomography"},{"key":"B6","doi-asserted-by":"publisher","first-page":"20160764","DOI":"10.1259\/bjr.20160764","article-title":"Radiotherapy response evaluation using FDG PET-CT-established and emerging applications","volume":"90","author":"Cliffe","year":"2017","journal-title":"Br J Radiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1007\/s11934-010-0105-9","article-title":"Imaging prostate cancer: an update on positron emission tomography and magnetic resonance imaging","volume":"11","author":"Bouchelouche","year":"2010","journal-title":"Curr Urol Rep."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/bjr\/tqaf020","article-title":"Clinical and research applications of FAPI tracers: a review","author":"Desaulniers","year":"2025","journal-title":"Br J Radiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1056\/NEJMoa2107322","article-title":"Lutetium-177-PSMA-617 for metastatic castration-resistant prostate","volume":"385","author":"Sartor","year":"2021","journal-title":"Cancer N Engl J Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"117829","DOI":"10.1016\/j.ejmech.2025.117829","article-title":"PSMA targeted therapy: from molecular mechanisms to clinical breakthroughs in castration-resistant prostate cancer","volume":"296","author":"Wang","year":"2025","journal-title":"Eur J Med Chem."},{"key":"B11","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.radonc.2019.01.033","article-title":"The dosimetric effect of residual breath-hold motion in pencil beam scanned proton therapy - an experimental study","volume":"134","author":"Gorgisyan","year":"2019","journal-title":"Radiother Oncol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"103196","DOI":"10.1016\/j.ejmp.2023.103196","article-title":"Implementation of dosimetry for molecular radiotherapy; results from a European survey","volume":"117","author":"Peters","year":"2024","journal-title":"Phys Med."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17152470","article-title":"Strategies for offline adaptive Biology-guided Radiotherapy (BgRT) on a PET-linac platform","author":"Cai","year":"2025","journal-title":"Cancers"},{"key":"B14","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.semradonc.2010.11.004","article-title":"The promise and pitfalls of positron emission tomography and single-photon emission computed tomography molecular imaging-guided radiation therapy","volume":"21","author":"Wahl","year":"2011","journal-title":"Semin Radiat Oncol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"4101","DOI":"10.3390\/cancers13164101","article-title":"First comparison between [18f]-FMISO and [18f]-FAZA for preoperative pet imaging of hypoxia in lung cancer","volume":"13","author":"Thureau","year":"2021","journal-title":"Cancers"},{"key":"B16","doi-asserted-by":"publisher","first-page":"532","DOI":"10.2967\/jnumed.112.105999","article-title":"18F-FLT PET during radiotherapy or chemoradiotherapy in head and neck squamous cell carcinoma is an early predictor of outcome","volume":"54","author":"Hoeben","year":"2013","journal-title":"J Nucl Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.eururo.2024.01.012","article-title":"Impact of prostate-specific membrane antigen positron emission tomography\/computed tomography on prostate cancer salvage radiotherapy management: results from a prospective multicenter randomized phase 3 trial (PSMA-SRT NCT03582774)","volume":"86","author":"Armstrong","year":"2024","journal-title":"Eur Urol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"104552","DOI":"10.1016\/j.critrevonc.2024.104552","article-title":"The role of amino acid PET in radiotherapy target volume delineation for adult-type diffuse gliomas: a review of the literature","volume":"205","author":"Horsley","year":"2025","journal-title":"Crit Rev Oncol Hematol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1016\/j.ijrobp.2006.03.015","article-title":"Posttreatment assessment of response using FDG-PET\/CT for patients treated with definitive radiation therapy for head and neck cancers","volume":"65","author":"Andrade","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"B20","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1056\/NEJMoa1607427","article-title":"Phase 3 trial of 117Lu-dotatate for midgut neuroendocrine tumors","volume":"376","author":"Strosberg","year":"2017","journal-title":"N Engl J Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"522","DOI":"10.3390\/ph18040522","article-title":"Fibroblast activation protein inhibitor (FAPI)-based theranostics","volume":"18","author":"Serumula","year":"2025","journal-title":"Pharmaceuticals"},{"key":"B22","doi-asserted-by":"publisher","first-page":"20150042","DOI":"10.1259\/bjr.20150042","article-title":"Improving external beam radiotherapy by combination with internal irradiation","volume":"88","author":"Dietrich","year":"2015","journal-title":"Br J Radiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1093\/jrr\/rraf002","article-title":"Investigation of the safety of Radium-223 chloride in combination with external beam radiotherapy for bone metastases of prostate cancer","volume":"66","author":"Makino","year":"2025","journal-title":"J Radiat Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2560","DOI":"10.7150\/thno.93249","article-title":"Exploring the role of combined external beam radiotherapy and targeted radioligand therapy with [177Lu]Lu-PSMA-617 for prostate cancer - from bench to bedside","volume":"14","author":"Arbuznikova","year":"2024","journal-title":"Theranostics"},{"key":"B25","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.radonc.2020.10.016","article-title":"Non-invasive imaging prediction of tumor hypoxia: a novel developed and externally validated CT and FDG-PET-based radiomic signatures","volume":"153","author":"Sanduleanu","year":"2020","journal-title":"Radiother Oncol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1183471","DOI":"10.3389\/fnume.2023.1183471","article-title":"Tumor microenvironment and fibroblast activation protein inhibitor (FAPI) PET: developments toward brain imaging","volume":"3","author":"Djekidel","year":"2023","journal-title":"Front Nucl Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1007\/s11307-023-01857-y","article-title":"Alpha particle\u2013emitting radiopharmaceuticals as cancer therapy: biological basis, current status, and future outlook for therapeutics discovery","volume":"25","author":"Coll","year":"2023","journal-title":"Mol Imaging Biol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.3390\/cancers14051152","article-title":"Stereotactic body radiation therapy in patients with oligometastatic disease: clinical state of the art and perspectives","volume":"14","author":"Kinj","year":"2022","journal-title":"Cancers"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.3390\/diagnostics13122018","article-title":"FAPI PET\/CT imaging-an updated review","volume":"13","author":"Chandekar","year":"2023","journal-title":"Diagnostics"},{"key":"B30","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3390\/tomography11060068","article-title":"Applications of advanced imaging for radiotherapy planning and response assessment in the central nervous system","volume":"11","author":"Lawrence","year":"2025","journal-title":"Tomography"},{"key":"B31","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/S1470-2045(25)00009-9","article-title":"Overall survival and quality of life with [177Lu]Lu-PSMA-617 plus enzalutamide versus enzalutamide alone in metastatic castration-resistant prostate cancer (ENZA-p): secondary outcomes from a multicentre, open-label, randomised, phase 2 trial Lancet Oncol","volume":"26","author":"Emmett","year":"2025"},{"key":"B32","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.radonc.2015.07.013","article-title":"PET-based dose painting in non-small cell lung cancer: comparing uniform dose escalation with boosting hypoxic and metabolically active sub-volumes","volume":"116","author":"Even","year":"2015","journal-title":"Radiother Oncol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"e545","DOI":"10.1016\/S1470-2045(24)00407-8","article-title":"Radiotherapy and theranostics: a lancet oncology commission","volume":"25","author":"Abdel-Wahab","year":"2024","journal-title":"Lancet Oncol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"238","DOI":"10.23736\/S1824-4785.22.03405-7","article-title":"Application of a smart 18F-FDG-PET adaptive threshold segmentation algorithm for the biological target volume delineation in head and neck cancer","volume":"67","author":"Deantonio","year":"2023","journal-title":"Q J Nucl Med Mol Imaging."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.2967\/jnumed.124.269378","article-title":"Rethinking dosimetry: a European perspective","volume":"66","author":"Tran-Gia","year":"2025","journal-title":"J Nucl Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"909","DOI":"10.2967\/jnumed.123.267321","article-title":"Safety and efficacy of extended therapy with [(177)Lu]Lu-PSMA: a German multicenter study","volume":"65","author":"Seifert","year":"2024","journal-title":"J Nucl Med."},{"key":"B37","doi-asserted-by":"publisher","first-page":"83","DOI":"10.2307\/3579648","article-title":"The linear-quadratic model and most other common radiobiological models result in similar predictions of time-dose relationships","volume":"150","author":"Brenner","year":"1998","journal-title":"Radiat Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"3391","DOI":"10.1002\/mp.12984","article-title":"Impact of interpatient variability on organ dose estimates according to MIRD schema: uncertainty and variance-based sensitivity analysis","volume":"45","author":"Zvereva","year":"2018","journal-title":"Med Phys."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1016\/j.ijrobp.2024.02.005","article-title":"Voxel-Level Dosimetry for combined iodine 131 radiopharmaceutical therapy and external beam radiation therapy treatment paradigms for head and neck cancer","volume":"119","author":"Adam","year":"2024","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"B40","doi-asserted-by":"publisher","first-page":"3","DOI":"10.2967\/jnumed.116.184028","article-title":"Total-Body PET: maximizing sensitivity to create new opportunities for clinical research and patient care","volume":"59","author":"Cherry","year":"2018","journal-title":"J Nucl Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"426","DOI":"10.3390\/diagnostics12020426","article-title":"Advantages and applications of Total-Body PET scanning","volume":"12","author":"Katal","year":"2022","journal-title":"Diagnostics"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.2967\/jnumed.121.263145","article-title":"Radioembolization dosimetry with Total-Body 90Y PET","volume":"63","author":"Costa","year":"2022","journal-title":"J Nucl Med."},{"key":"B43","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s13550-023-01059-1","article-title":"Performance and application of the total-body PET\/CT scanner: a literature review","volume":"14","author":"Sun","year":"2024","journal-title":"EJNMMI Res."},{"key":"B44","doi-asserted-by":"publisher","first-page":"2836","DOI":"10.1007\/s00259-020-04859-y","article-title":"Fibroblast activation protein inhibitor (FAPI) PET for diagnostics and advanced targeted radiotherapy in head and neck cancers","volume":"47","author":"Syed","year":"2020","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"B45","doi-asserted-by":"publisher","first-page":"880","DOI":"10.2967\/jnumed.123.267248","volume":"65","author":"Lanzafame","year":"2024","journal-title":"J Nucl Med."},{"key":"B46","doi-asserted-by":"publisher","first-page":"32","DOI":"10.2174\/1874471008666150316222400","article-title":"Hypoxia PET tracers in EBRT dose planning in head and neck cancer","volume":"8","author":"Hodoli\u010d","year":"2015","journal-title":"Curr Radiopharm."},{"key":"B47","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1088\/1361-6560\/ac88b3","article-title":"Personalized mid-course FDG-PET based adaptive treatment planning for non-small cell lung cancer using machine learning and optimization","author":"Ajdari","year":"2022","journal-title":"Phys Med Biol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s13550-025-01226-6","article-title":"Mid-treatment changes in intra-tumoural metabolic heterogeneity correlate to outcomes in oropharyngeal squamous cell carcinoma patients","volume":"15","author":"Trada","year":"2025","journal-title":"EJNMMI Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s13014-019-1232-1","article-title":"Prognostic values of mid-radiotherapy 18F-FDG PET\/CT in patients with esophageal cancer","volume":"14","author":"Kim","year":"2019","journal-title":"Radiat Oncol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13014-018-0983-4","article-title":"Outcome after PSMA PET\/CT based radiotherapy in patients with biochemical persistence or recurrence after radical prostatectomy","volume":"13","author":"Schmidt-Hegemann","year":"2018","journal-title":"Radiat Oncol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"995","DOI":"10.2967\/jnumed.124.268071","article-title":"Treatment response evaluation in prostate cancer using PSMA PET\/CT","volume":"66","author":"Gafita","year":"2025","journal-title":"J Nucl Med."},{"key":"B52","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s13014-020-01519-1","article-title":"Recent advances of PET imaging in clinical radiation oncology","volume":"15","author":"Unterrainer","year":"2020","journal-title":"Radiat Oncol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s12149-022-01820-x","article-title":"A review of harmonization strategies for quantitative PET","volume":"37","author":"Akamatsu","year":"2023","journal-title":"Ann Nucl Med."},{"key":"B54","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.radonc.2008.11.008","article-title":"Use of PET and PET\/CT for radiation therapy planning: IAEA expert report 2006\u20132007","volume":"91","author":"MacManus","year":"2009","journal-title":"Radiother Oncol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.zemedi.2022.09.001","article-title":"Clinical use of positron emission tomography for radiotherapy planning - medical physics considerations","volume":"33","author":"Thorwarth","year":"2023","journal-title":"Z Med Phys."},{"key":"B56","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s00259-017-3740-2","article-title":"EANM\/EARL harmonization strategies in PET quantification: from daily practice to multicentre oncological studies","volume":"44","author":"Aide","year":"2017","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"B57","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s40658-018-0235-6","article-title":"Impact of PET reconstruction protocols on quantification of lesions that fulfil the PERCIST lesion inclusion criteria","volume":"5","author":"Devriese","year":"2018","journal-title":"EJNMMI Phys."},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.121.262754","article-title":"Dosimetry for radiopharmaceutical therapy: the European perspective","author":"Lassmann","year":"2021","journal-title":"J Nucl Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.2967\/jnumed.124.269424","article-title":"Recommendations for standardizing nuclear medicine terminology and data in the era of theranostics and artificial intelligence","volume":"66","author":"Bradshaw","year":"2025","journal-title":"J Nucl Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1686593","DOI":"10.3389\/fmed.2025.1686593","article-title":"Innovative approaches in precision radiation oncology: advanced imaging technologies and challenges which shape the future of radiation therapy","volume":"12","author":"Yan","year":"2025","journal-title":"Front Med."},{"key":"B61","doi-asserted-by":"publisher","first-page":"24","DOI":"10.21037\/cco-23-143","article-title":"Advancements and future directions in positron emission tomography-guided radiotherapy: a narrative review","volume":"13","author":"Mehta","year":"2024","journal-title":"Chin Clin Oncol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/2001-1326-1-18","article-title":"Challenges and opportunities in patient-specific, motion-managed and PET\/CT-guided radiation therapy of lung cancer: review and perspective","volume":"1","author":"Bowen","year":"2012","journal-title":"Clin Transl Med."},{"key":"B63","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/j.ijrobp.2020.12.002","article-title":"Overcoming barriers to radiopharmaceutical therapy (RPT): an overview from the NRG-NCI working group on dosimetry of radiopharmaceutical therapy","volume":"109","author":"Divgi","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"B64","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s40644-022-00505-y","article-title":"Use of imaging-based dosimetry for personalising radiopharmaceutical therapy of cancer","volume":"22","author":"Beauregard","year":"2022","journal-title":"Cancer Imaging."},{"key":"B65","doi-asserted-by":"publisher","first-page":"4184","DOI":"10.1007\/s00259-025-07262-7","article-title":"Insights into pet-based radiogenomics in oncology: an updated systematic review","volume":"52","author":"Filippi","year":"2025","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"B66","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.cpet.2025.01.002","article-title":"Current and future applications of PET radiomics in radiation oncology","volume":"20","author":"Fan","year":"2025","journal-title":"PET Clin."},{"key":"B67","doi-asserted-by":"publisher","first-page":"748","DOI":"10.2967\/jnumed.124.268186","article-title":"Computational nuclear oncology toward precision radiopharmaceutical therapies: ethical, regulatory, and socioeconomic dimensions of theranostic digital twins","volume":"66","author":"Strigari","year":"2025","journal-title":"J Nucl Med."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1794722\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:09:59Z","timestamp":1776262199000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1794722\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,15]]},"references-count":67,"alternative-id":["10.3389\/fmed.2026.1794722"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1794722","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,15]]},"article-number":"1794722"}}